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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : Biochemical and biophysical research communications

The actin propulsive machinery: the proteome of Listeria monocytogenes tails

Team: Bacteria-Cell Interactions
Member: Pascale Cossart
Member: Javier Pizarro-Cerda
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biochemical and biophysical research communications - 09 Aug 2008

Van Troys M, Lambrechts A, David V, Demol H, Puype M, Pizarro-Cerda J, Gevaert K, Cossart P, Vandekerckhove J

Link to Pubmed [PMID] – 18694727

Biochem. Biophys. Res. Commun. 2008 Oct;375(2):194-9

Actin-based comet tails produced by Listeria monocytogenes are considered as representative models for cellular force-producing machineries crucial for cell migration. We here present a proteomic picture of these tails formed in extracts from brain and platelets. This provides a comprehensive view, revealing high molecular complexity and novel host cell proteins as tail components, and suggests the participation of specific multicomponent regulatory complexes. This work forms a new basis to expand current models of cellular protrusion.