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© Institut Pasteur
Cryptococcus neoformans
Publication : Nature communications

Systematic functional profiling of transcription factor networks in Cryptococcus neoformans

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature communications - 07 Apr 2015

Jung KW, Yang DH, Maeng S, Lee KT, So YS, Hong J, Choi J, Byun HJ, Kim H, Bang S, Song MH, Lee JW, Kim MS, Kim SY, Ji JH, Park G, Kwon H, Cha S, Meyers GL, Wang LL, Jang J, Janbon G, Adedoyin G, Kim T, Averette AK, Heitman J, Cheong E, Lee YH, Lee YW, Bahn YS

Link to Pubmed [PMID] – 25849373

Nat Commun 2015;6:6757

Cryptococcus neoformans causes life-threatening meningoencephalitis in humans, but its overall biological and pathogenic regulatory circuits remain elusive, particularly due to the presence of an evolutionarily divergent set of transcription factors (TFs). Here, we report the construction of a high-quality library of 322 signature-tagged gene-deletion strains for 155 putative TF genes previously predicted using the DNA-binding domain TF database, and examine their in vitro and in vivo phenotypic traits under 32 distinct growth conditions. At least one phenotypic trait is exhibited by 145 out of 155 TF mutants (93%) and ∼85% of them (132/155) are functionally characterized for the first time in this study. The genotypic and phenotypic data for each TF are available in the C. neoformans TF phenome database (http://tf.cryptococcus.org). In conclusion, our phenome-based functional analysis of the C. neoformans TF mutant library provides key insights into transcriptional networks of basidiomycetous fungi and human fungal pathogens.

http://www.ncbi.nlm.nih.gov/pubmed/25849373