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© Therese Couderc, Marc Lecuit
Publication : Medical mycology

Success of posaconazole therapy in a heart transplanted patient with Alternaria infectoria cutaneous infection.

Team: Biology of infection
Team: Fungal Biology and Pathogenicity
Member: Marc Lecuit
Member: Caroline Charlier-Woerther
Member: Marie-Elisabeth Bougnoux
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Medical mycology - 05 Dec 2011

Rammaert B, Aguilar C, Bougnoux ME, Noël N, Charlier C, Denis B, Lecuit M, Lortholary O,

Link to Pubmed [PMID] – 22142219

Link to DOI – 10.3109/13693786.2011.641165

Med Mycol 2012 Jul; 50(5): 518-21

Cutaneous Alternaria spp. infections occur mainly in immunosuppressed patients and itraconazole is considered as the drug of choice. We report the case of a 64-year-old heart transplanted female patient with multiple cutaneous lesions caused by Alternaria infectoria. Treatment with posaconazole resulted in complete recovery. Due to lower minimal inhibitory concentrations, better distribution and less drug interactions than with itraconazole, posaconazole may become the antifungal drug to consider in the management of cutaneous infections caused by Alternaria spp. in solid organ transplant recipients.