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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : Nature cell biology

Subversion of phosphoinositide metabolism by intracellular bacterial pathogens

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature cell biology - 01 Nov 2004

Pizarro-Cerdá J, Cossart P

Link to Pubmed [PMID] – 15516995

Nat. Cell Biol. 2004 Nov;6(11):1026-33

Phosphoinositides are short-lived lipids, whose production at specific membrane locations in the cell enables the tightly controlled recruitment or activation of diverse cellular effectors involved in processes such as cell motility or phagocytosis. Bacterial pathogens have evolved molecular mechanisms to subvert phosphoinositide metabolism in host cells, promoting (or blocking) their internalization into target tissues, and/or modifying the maturation fate of their proliferating compartments within the intracellular environment.

http://www.ncbi.nlm.nih.gov/pubmed/15516995