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© Christelle Durand
Microscopie d'un neurone. Le marquage jaune montre les synapses.
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature medicine - 06 Jun 2013

Delorme R, Ey E, Toro R, Leboyer M, Gillberg C, Bourgeron T

Link to Pubmed [PMID] – 23744158

Nat. Med. 2013 Jun;19(6):685-94

Autism spectrum disorder (ASD) encompasses a range of disorders that are characterized by social and communication deficits and repetitive behaviors. For the majority of affected individuals, the cause of ASD remains unknown, but in at least 20% of the cases, a genetic cause can be identified. There is currently no cure for ASD; however, results from mouse models indicate that some forms of the disorder could be alleviated even at the adult stage. Genes involved in ASD seem to converge on common pathways altering synaptic homeostasis. We propose, given the clinical heterogeneity of ASD, that specific ‘synaptic clinical trials’ should be designed and launched with the aim of establishing whether phenotype ‘reversals’ could also occur in humans.

http://www.ncbi.nlm.nih.gov/pubmed/23744158