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© Melody Merle
Fluorescently labeled five day old gastruloid, a mouse embryonic stem-cell derived pseudo-embryo.
Publication : Nature structural & molecular biology

Precise and scalable self-organization in mammalian pseudo-embryos.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature structural & molecular biology - 15 Mar 2024

Merle M, Friedman L, Chureau C, Shoushtarizadeh A, Gregor T

Link to Pubmed [PMID] – 38491138

Link to DOI – 10.1038/s41594-024-01251-4

Nat Struct Mol Biol 2024 Mar; ():

Gene expression is inherently noisy, posing a challenge to understanding how precise and reproducible patterns of gene expression emerge in mammals. Here we investigate this phenomenon using gastruloids, a three-dimensional in vitro model for early mammalian development. Our study reveals intrinsic reproducibility in the self-organization of gastruloids, encompassing growth dynamics and gene expression patterns. We observe a remarkable degree of control over gene expression along the main body axis, with pattern boundaries positioned with single-cell precision. Furthermore, as gastruloids grow, both their physical proportions and gene expression patterns scale proportionally with system size. Notably, these properties emerge spontaneously in self-organizing cell aggregates, distinct from many in vivo systems constrained by fixed boundary conditions. Our findings shed light on the intricacies of developmental precision, reproducibility and size scaling within a mammalian system, suggesting that these phenomena might constitute fundamental features of multicellularity.