The topological reorganization imposed on the chromatin during mitosis leads to a global shutdown of the gene expression. How then is the transcriptional program reestablished after division ? Previous work lacks the coupling between spatial and temporal resolution to assess in real-time the interplay between the transcriptional machinery and the physical properties of the chromatin. The goal of this project is to investigate gene regulation with high spatial and temporal resolution before, during and just after mitosis. Using quantitative imaging we will monitor enhancer-promoter contacts and continuously record transcriptional activity, particularly as cells undergo mitosis. Computational and statistical analyses as well as polymer models will be developed to quantify dynamic interactions and associate them to TF activity, mitotic progression and transcriptional outputs.
Publications
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Microbial Paleogenomics UnitNicolás Rascovan
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Mechanisms of epigenetic inheritanceGermano Cecere
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Production and Purification of Recombinant Proteins Technological PlatformStéphane Petres
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Stem Cells And DevelopmentShahragim Tajbakhsh
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Malaria Infection & ImmunityRogerio Amino
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Integrative Structural Cell BiologyAriane Briegel
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Imaging and pathophysiology of Klebsiella pneumoniae and Klebsiella rhinoscleromatis infectionsRégis Tournebize
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RESPIMOD: Modelling Interactions within Respiratory TractLulla Opatowski
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Mouse Genome-Wide GenotypingSean Kennedy
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The phylodynamics of partner notification and contact tracing in HIV epidemicsAnna Zhukova
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QUOBIINathalie Sauvonnet
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Analysis and modelling to support decision making during epidemicsSimon Cauchemez