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© Institut Pasteur
Cryptococcus neoformans
Publication : G3 (Bethesda, Md.)

Population genomic analysis of Cryptococcus Brazilian isolates reveals an African type subclade distribution.

Team: RNA Biology of Fungal Pathogens
Member: Guilhem Janbon
Member: Olivier Cordin
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in G3 (Bethesda, Md.) - 02 Apr 2021

Maufrais C, de Oliveira L, Bastos RW, Moyrand F, Reis FCG, Valero C, Gimenez B, Josefowicz LJ, Goldman GH, Rodrigues ML, Janbon G,

Link to Pubmed [PMID] – 33822048

Link to DOI – jkab10710.1093/g3journal/jkab107

G3 (Bethesda) 2021 Apr; ():

The genomes of a large number of Cryptococcus neoformans isolates have been sequenced and analyzed in recent years. These genomes have been used to understand the global population structure of this opportunistic pathogen. However, only a small number of South American isolates have been considered in these studies, and the population structure of C. neoformans in this part of the world remains elusive. Here, we analyzed the genomic sequences of 53 Brazilian Cryptococcus isolates and deciphered the C. neoformans population structure in this country. Our data reveal an African-like structure that suggested repeated intercontinental transports from Africa to South America. We also identified a mutator phenotype in one VNBII Brazilian isolate, exemplifying how fast-evolving isolates can shape the Cryptococcus population structure. Finally, phenotypic analyses revealed wide diversity but not lineage specificity in the expression of classical virulence traits within the set of isolates.