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© Christelle Durand
Microscopie d'un neurone. Le marquage jaune montre les synapses.
Publication : Cerebral cortex (New York, N.Y. : 1991)

Polygenic Architecture of Human Neuroanatomical Diversity.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cerebral cortex (New York, N.Y. : 1991) - 14 Apr 2020

Biton A, Traut N, Poline JB, Aribisala BS, Bastin ME, Bülow R, Cox SR, Deary IJ, Fukunaga M, Grabe HJ, Hagenaars S, Hashimoto R, Kikuchi M, Muñoz Maniega S, Nauck M, Royle NA, Teumer A, Valdés Hernández M, Völker U, Wardlaw JM, Wittfeld K, Yamamori H, , Bourgeron T, Toro R,

Link to Pubmed [PMID] – 32109272

Link to DOI [DOI] – 10.1093/cercor/bhz241

Cereb Cortex 2020 Apr; 30(4): 2307-2320

We analyzed the genomic architecture of neuroanatomical diversity using magnetic resonance imaging and single nucleotide polymorphism (SNP) data from >26 000 individuals from the UK Biobank project and 5 other projects that had previously participated in the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) consortium. Our results confirm the polygenic architecture of neuroanatomical diversity, with SNPs capturing from 40% to 54% of regional brain volume variance. Chromosomal length correlated with the amount of phenotypic variance captured, r ~ 0.64 on average, suggesting that at a global scale causal variants are homogeneously distributed across the genome. At a local scale, SNPs within genes (~51%) captured ~1.5 times more genetic variance than the rest, and SNPs with low minor allele frequency (MAF) captured less variance than the rest: the 40% of SNPs with MAF <5% captured <one fourth of the genetic variance. We also observed extensive pleiotropy across regions, with an average genetic correlation of rG ~ 0.45. Genetic correlations were similar to phenotypic and environmental correlations; however, genetic correlations were often larger than phenotypic correlations for the left/right volumes of the same region. The heritability of differences in left/right volumes was generally not statistically significant, suggesting an important influence of environmental causes in the variability of brain asymmetry. Our code is available athttps://github.com/neuroanatomy/genomic-architecture.

https://pubmed.ncbi.nlm.nih.gov/32109272