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© Christelle Durand
Microscopie d'un neurone. Le marquage jaune montre les synapses.
Publication : Journal of leukocyte biology

Nicotine and serotonin in immune regulation and inflammatory processes: a perspective

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of leukocyte biology - 15 Nov 2006

Cloëz-Tayarani I, Changeux JP

Link to Pubmed [PMID] – 17108054

J. Leukoc. Biol. 2007 Mar;81(3):599-606

Nicotine and serotonin modulate the innate and adaptive immune responses and the inflammatory states. Several nicotinic cholinergic and serotonergic receptor subtypes have been characterized in B and T lymphocytes, monocytes, macrophages, and dendritic cells. The use of knockout mice has allowed a better characterization of nicotinic receptors and their role in anti-inflammatory processes in these cells. Cytokines play a crucial role in controlling inflammatory reactions. Nicotine and serotonin have been reported to regulate cytokine release. Cholinergic mechanisms also play an important role in inflammation through endogenous acetylcholine. Nicotine mimics this effect by activating the cholinergic anti-inflammatory pathways. New concepts of reciprocal interactions between nicotine and serotonin are emerging. The role of nicotine as an anti-inflammatory agent has been established, whereas that of serotonin remains more controversial.

https://www.ncbi.nlm.nih.gov/pubmed/17108054