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© Research
Publication : European journal of immunology

Multiple survival signals are delivered by dendritic cells to naive CD4+ T cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in European journal of immunology - 01 Sep 2005

Feuillet V, Lucas B, Di Santo JP, Bismuth G, Trautmann A

Link to Pubmed [PMID] – 16078277

Eur. J. Immunol. 2005 Sep;35(9):2563-72

The molecular mechanisms by which dendritic cells (DC) favor naive T cell survival in mice have been examined in co-cultures of DC and naive CD4+ T cells. Naive T cells can survive in the presence of IL-4 or IL-7, but DC-induced T cell survival requires direct cell-cell interactions and does not seem to be mediated by these or other soluble factors. Classical MHC II molecules on DC are not necessary for T cell survival as long as hybrid AalphaEbeta MHC class II molecules are present. In the total absence of MHC II molecules on DC, T cell survival is reduced by half, and CD3zeta phosphorylation fully disappears. These results contrast with the classical view that naive T cell survival is associated with CD3zeta phosphorylation and depends mostly on IL-7 and MHC-TCR interactions. We demonstrate that DC-induced T cell survival is a multi-factorial process that also involves CD28, LFA-1 and another (as yet undefined) surface molecule that requires the activity of src (but not phosphatidylinositol-3-) kinase.

http://www.ncbi.nlm.nih.gov/pubmed/16078277