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© Christelle Durand
Microscopie d'un neurone. Le marquage jaune montre les synapses.
Publication : Cortex; a journal devoted to the study of the nervous system and behavior

Mechanical morphogenesis and the development of neocortical organisation

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cortex; a journal devoted to the study of the nervous system and behavior - 20 Mar 2018

Foubet O, Trejo M, Toro R

Link to Pubmed [PMID] – 30503630

Cortex 2019 Sep;118:315-326

The development of complex neocortical organisations is thought to result from the interaction of genetic and activity-dependent processes. We propose that a third type of process – mechanical morphogenesis – may also play an important role. We review theoretical and experimental results in physics showing how even homogeneous growth can produce a variety of forms, in particular neocortical folding. The mechanical instabilities that produce these forms induce heterogeneous patterns of stress at the scale of the organ. We review the evidence showing how these stresses can influence cell proliferation, migration and apoptosis, cell differentiation and shape, migration and axonal guidance, and could thus be able to influence regional neocortical identity and connectivity.

https://www.ncbi.nlm.nih.gov/pubmed/30503630