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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : Infection and immunity

LipA, a tyrosine and lipid phosphatase involved in the virulence of Listeria monocytogenes

Team: Bacteria-Cell Interactions
Member: Pascale Cossart
Member: Olivier Dussurget
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Infection and immunity - 28 Mar 2011

Kastner R, Dussurget O, Archambaud C, Kernbauer E, Soulat D, Cossart P, Decker T

Link to Pubmed [PMID] – 21444667

Infect. Immun. 2011 Jun;79(6):2489-98

Intracellular bacterial pathogens manipulate host cell functions by producing enzymes that stimulate or antagonize signal transduction. The Listeria monocytogenes genome contains a gene, lmo1800, encoding a protein with a conserved motif of conventional tyrosine phosphatases. Here, we report that the lmo1800-encoded protein LipA is secreted by Listeria and displays tyrosine as well as lipid phosphatase activity in vitro. Bacteria lacking LipA are severely attenuated in virulence in vivo, thus revealing a so-far-undescribed enzymatic activity involved in Listeria infection.

http://www.ncbi.nlm.nih.gov/pubmed/21444667