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© Institut Pasteur
Culture de myotubes murins infectés par le virus de la rage fixe, observée en immunoflorescence indirecte.
Publication : Journal of virology

Lassa virus nucleoprotein mutants generated by reverse genetics induce a robust type I interferon response in human dendritic cells and macrophages

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of virology - 31 Aug 2011

Carnec X, Baize S, Reynard S, Diancourt L, Caro V, Tordo N, Bouloy M

Link to Pubmed [PMID] – 21880754

J. Virol. 2011 Nov;85(22):12093-7

Lassa virus (LASV; Arenaviridae) is responsible for severe hemorrhagic fevers in Africa. LASV nucleoprotein (NP) plays important roles in regulating viral transcription and replication and in inhibiting type I interferon (IFN) production. The NP C-terminal domain contains a 3′-to-5′ exonuclease activity involved in suppressing IFN induction. We have established a murine polymerase (Pol) I reverse genetics system for LASV, showing that residues D389 and G392 of NP were critical for LASV viability, while the D389A/G392A and D389T/392A double mutants were severely altered in the ability to suppress IFN in macrophages and dendritic cells. Assessing their attenuation in vivo may open new perspectives in vaccinology.

https://www.ncbi.nlm.nih.gov/pubmed/21880754