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© Pierre Gounon
Culture de cellules infectées par le virus Ebola, virus isolé sur un malade de Côte d'Ivoire par Leguenno en 1995. Virus de la famille des Filoviridae genre Filovirus. Réservoir naturel et mode de transmission inconnus. Infections secondaires par contact direct avec sang contaminé ou sécrétions corporelles. Mortalité dans 50 à 90% des cas. Soudan, République Démocratique du Congo, Côte d'Ivoire (Grossissement X 40000).
Publication : Journal of virology

Lassa virus nucleoprotein mutants generated by reverse genetics induce a robust type I interferon response in human dendritic cells and macrophages

Team: Biology of Viral Emerging Infections
Team: Environment and Infectious Risks
Member: Noël Tordo
Member: Sylvain Baize
Member: Laure Diancourt
Member: Mathieu Mateo
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of virology - 31 Aug 2011

Carnec X, Baize S, Reynard S, Diancourt L, Caro V, Tordo N, Bouloy M

Link to Pubmed [PMID] – 21880754

J. Virol. 2011 Nov;85(22):12093-7

Lassa virus (LASV; Arenaviridae) is responsible for severe hemorrhagic fevers in Africa. LASV nucleoprotein (NP) plays important roles in regulating viral transcription and replication and in inhibiting type I interferon (IFN) production. The NP C-terminal domain contains a 3′-to-5′ exonuclease activity involved in suppressing IFN induction. We have established a murine polymerase (Pol) I reverse genetics system for LASV, showing that residues D389 and G392 of NP were critical for LASV viability, while the D389A/G392A and D389T/392A double mutants were severely altered in the ability to suppress IFN in macrophages and dendritic cells. Assessing their attenuation in vivo may open new perspectives in vaccinology.