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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : Trends in microbiology

Interdependence of mycobacterial iron regulation, oxidative-stress response and isoniazid resistance.

Team: Bacteria-Cell Interactions
Team: Group : Bacterial Pathogenesis and Antibacterial Agents
Team: Yersinia
Member: Olivier Dussurget
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in microbiology - 01 Sep 1998

Dussurget O, Smith I,

Link to Pubmed [PMID] – 9778728

Trends Microbiol 1998 Sep; 6(9): 354-8

Iron is an essential cofactor for vital functions in microorganisms. Bacterial pathogens have developed efficient iron-acquisition systems to counteract the defensive sequestration of iron by their hosts. In mycobacteria, the recently described protein, IdeR, negatively controls iron-uptake systems. This protein also has a role in the oxidative-stress response, as well as in resistance to the frontline antimycobacterial drug isoniazid.