Link to Pubmed [PMID] – 9778728
Trends Microbiol. 1998 Sep;6(9):354-8
Iron is an essential cofactor for vital functions in microorganisms. Bacterial pathogens have developed efficient iron-acquisition systems to counteract the defensive sequestration of iron by their hosts. In mycobacteria, the recently described protein, IdeR, negatively controls iron-uptake systems. This protein also has a role in the oxidative-stress response, as well as in resistance to the frontline antimycobacterial drug isoniazid.
http://www.ncbi.nlm.nih.gov/pubmed/9778728