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© J.M. Ghigo (Institut Pasteur) and Brigite Arbeille (LBC-ME. Faculté de Médecine de Tours)
Colorized scanning electron microscopy of an E. coli biofilm developing on a glass surface
Publication : The Journal of antimicrobial chemotherapy

In vitro activity of gentamicin, vancomycin or amikacin combined with EDTA or l-arginine as lock therapy against a wide spectrum of biofilm-forming clinical strains isolated from catheter-related infections

Team: Genetics of Biofilms
Team: Group: Christophe Beloin
Member: Jean-Marc Ghigo
Member: Christophe Beloin
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of antimicrobial chemotherapy - 23 Feb 2015

Lebeaux D, Leflon-Guibout V, Ghigo JM, Beloin C

Link to Pubmed [PMID] – 25712314

J. Antimicrob. Chemother. 2015 Jun;70(6):1704-12

Treatment of catheter-related bloodstream infections (CRBSI) is hampered by the characteristic tolerance of bacterial biofilms towards antibiotics. Our objective was to study the effect of the combination of antibiotics and the alkaline amino acid l-arginine or the cation chelator EDTA on the bacterial killing of in vitro biofilms formed by an array of clinical strains responsible for CRBSI and representative of epidemiologically relevant bacterial species.