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© Research
Publication : Skeletal muscle

Immortalized pathological human myoblasts: towards a universal tool for the study of neuromuscular disorders

Team: Innate Immunity
Member: James Di Santo
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Skeletal muscle - 01 Nov 2011

Mamchaoui K, Trollet C, Bigot A, Negroni E, Chaouch S, Wolff A, Kandalla PK, Marie S, Di Santo J, St Guily JL, Muntoni F, Kim J, Philippi S, Spuler S, Levy N, Blumen SC, Voit T, Wright WE, Aamiri A, Butler-Browne G, Mouly V

Link to Pubmed [PMID] – 22040608

Skelet Muscle 2011;1:34

Investigations into both the pathophysiology and therapeutic targets in muscle dystrophies have been hampered by the limited proliferative capacity of human myoblasts. Isolation of reliable and stable immortalized cell lines from patient biopsies is a powerful tool for investigating pathological mechanisms, including those associated with muscle aging, and for developing innovative gene-based, cell-based or pharmacological biotherapies.

http://www.ncbi.nlm.nih.gov/pubmed/22040608