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© Therese Couderc, Marc Lecuit
Publication : Emerging infectious diseases

Human polyomavirus related to African green monkey lymphotropic polyomavirus

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Emerging infectious diseases - 01 Aug 2011

Sauvage V, Foulongne V, Cheval J, Ar Gouilh M, Pariente K, Dereure O, Manuguerra JC, Richardson J, Lecuit M, Burguière A, Caro V, Eloit M

Link to Pubmed [PMID] – 21801611

Emerging Infect. Dis. 2011 Aug;17(8):1364-70

While studying the virome of the skin surface of a patient with a Merkel cell carcinoma (MCC) by using unbiased, high-throughput sequencing, we identified a human polyomavirus nearly identical to human polyomavirus 9, a virus recently reported in blood and urine of renal transplantion patients and closely related to the African green monkey lymphotropic polyomavirus. Specific PCR analysis further identified this virus in 2/8 patients with MCC but in only 1/111 controls without MCC. This virus was shed for ≥20 months by the MCC index patient and was on the skin of the spouse of the index patient. These results provide information on the viral ecology of human skin and raise new questions regarding the pathology of virus-associated skin disorders.

http://www.ncbi.nlm.nih.gov/pubmed/21801611