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© Research
Publication : Current opinion in microbiology

Group 3 innate lymphoid cells mediate host defense against attaching and effacing pathogens.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in microbiology - 15 Jul 2021

Jarade A, Di Santo JP, Serafini N,

Link to Pubmed [PMID] – 34274597

Link to DOI – S1369-5274(21)00080-110.1016/j.mib.2021.06.005

Curr Opin Microbiol 2021 Jul; 63(): 83-91

Group 3 innate lymphoid cells (ILC3) are innate effector cells that have essential roles in lymphoid organogenesis and maintenance of tissue homeostasis under steady-state and pathogenic conditions. ILC3 also promote immune defense, notably during bacterial breach of epithelial barriers, including those caused by attaching and effacing (A/E) pathogens for which Citrobacter rodentium infection in mice is a relevant pre-clinical model. Through their ability to sustain interactions with tissue-resident immune cells, epithelial cells, neurons or stromal cells, ILC3 constitute a key orchestrator that maintains the intestinal barrier. In this review, we will examine the function of murine ILC3 in host defense against C. rodentium infection and provide a discussion of recent advances that help elucidate the specific roles of these novel innate immune effector cells at mucosal surfaces.

https://pubmed.ncbi.nlm.nih.gov/34274597