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© Research
Publication : Nature microbiology

Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature microbiology - 02 Jan 2025

Vaysset H, Meers C, Cury J, Bernheim A, Sternberg SH

Link to Pubmed [PMID] – 39747689

Link to DOI – 10.1038/s41564-024-01889-2

Nat Microbiol 2025 Jan; ():

Transposase genes are ubiquitous in all domains of life and provide a rich reservoir for the evolution of novel protein functions. Here we report deep evolutionary links between bacterial IS110-family transposases, which catalyse RNA-guided DNA recombination using bridge RNAs, and archaeal/eukaryotic Nop5-family proteins, which promote RNA-guided RNA 2′-O-methylation using C/D-box snoRNAs. On the basis of conservation of protein sequence, domain architecture, three-dimensional structure and non-coding RNA features, alongside phylogenetic analyses, we propose that programmable RNA modification emerged through the exaptation of components derived from IS110-like transposons. These findings underscore how recurrent domestication events of transposable elements have driven the evolution of RNA-guided mechanisms.