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© Research
Publication : The Journal of infectious diseases

Human leukocyte antigen class II alleles may contribute to the severity of hepatitis C virus-related liver disease

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of infectious diseases - 31 May 2002

Hüe S, Cacoub P, Renou C, Halfon P, Thibault V, Charlotte F, Picon M, Rifflet H, Piette JC, Pol S, Caillat-Zucman S

Link to Pubmed [PMID] – 12089669

J. Infect. Dis. 2002 Jul;186(1):106-9

Whether the host’s immune response genes influence the severity of hepatitis C virus (HCV) liver disease is controversial. Human leukocyte antigen (HLA) class II alleles were analyzed in 233 HCV RNA-positive patients with chronic active hepatitis (197 patients with Knodell index of fibrosis F0-F3 and 36 patients with index of F4). The 2 groups did not differ by sex, duration of infection, mode of contamination, alcohol consumption, or HCV genotype. Patients with cirrhosis were older than those without (56+/-12 vs. 46+/-14 years; P50 years. HLA class II alleles may weakly contribute to the severity of HCV liver disease. Of persons infected with HCV, only 15%-20% spontaneously clear the virus, and the rest become chronically infected.

https://www.ncbi.nlm.nih.gov/pubmed/12089669