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© Research
Publication : Bioorganic & medicinal chemistry letters

Discovery of novel small molecule cell type-specific enhancers of NF-kappaB nuclear translocation

Team: Photonic BioImaging (UTechS PBI)
Member: Nathalie Aulner
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Bioorganic & medicinal chemistry letters - 25 Dec 2008

Gong G, Xie Y, Liu Y, Rinderspacher A, Deng SX, Feng Y, Zhu Z, Tang Y, Wyler M, Aulner N, Toebben U, Smith DH, Branden L, Chung C, Schürer S, Vidović D, Landry DW

Link to Pubmed [PMID] – 19136257

Bioorg. Med. Chem. Lett. 2009 Feb;19(4):1191-4

An IKKbeta inhibitor reported to block NF-kappaB transcriptional activities in Jurkat T cells, was found to enhance NF-kappaB translocation in HUVEC cells. These studies suggested a noncanonical NF-kappaB signaling pathway independent of IKKbeta in HUVEC cells.