Discovery of novel small molecule cell type-specific enhancers of NF-kappaB nuclear translocation

Lien vers Pubmed [PMID] – 19136257

Bioorg. Med. Chem. Lett. 2009 Feb;19(4):1191-4

An IKKbeta inhibitor reported to block NF-kappaB transcriptional activities in Jurkat T cells, was found to enhance NF-kappaB translocation in HUVEC cells. These studies suggested a noncanonical NF-kappaB signaling pathway independent of IKKbeta in HUVEC cells.