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© Research
Publication : PloS one

Differential susceptibility of two field aedes aegypti populations to a low infectious dose of dengue virus

Team: Insect-Virus Interactions
Member: Louis Lambrechts
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 24 Mar 2014

Pongsiri A, Ponlawat A, Thaisomboonsuk B, Jarman RG, Scott TW, Lambrechts L

Link to Pubmed [PMID] – 24664142

PLoS ONE 2014;9(3):e92971

The infectious dose required to infect mosquito vectors when they take a blood meal from a viremic person is a critical parameter underlying the probability of dengue virus (DENV) transmission. Because experimental vector competence studies typically examine the proportion of mosquitoes that become infected at intermediate or high DENV infectious doses in the blood meal, the minimum blood meal titer required to infect mosquitoes is poorly documented. Understanding the factors influencing the lower infectiousness threshold is epidemiologically significant because it determines the transmission potential of humans with a low DENV viremia, possibly including inapparent infections, and during the onset and resolution of the viremic period of acutely infected individuals.