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© Research
Publication : The Journal of infectious diseases

HIV-1 infection impairs regulatory T-cell suppressive capacity on a per-cell basis

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of infectious diseases - 23 Mar 2014

Angin M, Sharma S, King M, Murooka TT, Ghebremichael M, Mempel TR, Walker BD, Bhasin MK, Addo MM

Link to Pubmed [PMID] – 24664171

J. Infect. Dis. 2014 Sep;210(6):899-903

The impact of CD4+ regulatory T cells (Tregs) on human immunodeficiency virus type 1 (HIV-1) pathogenesis remains incompletely understood. Although it has been shown that Tregs can be infected with HIV-1, the consequences of infection on a per-cell basis are still unknown. In vitro HIV-GFP infected and noninfected Tregs were isolated by flow-based cell-sorting to investigate Treg suppressive capacity and gene expression profiles. Our data show that HIV-1-infected Tregs were significantly less suppressive than noninfected Tregs and demonstrated down-regulation of genes critical to Treg function. This impaired function may have detrimental consequences for the control of generalized immune activation and accelerate HIV disease progression.

http://www.ncbi.nlm.nih.gov/pubmed/24664171