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© Therese Couderc, Marc Lecuit
Publication : Ocular immunology and inflammation

Diagnosis and Treatment of Listeria monocytogenes Endophthalmitis: A Systematic Review

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Ocular immunology and inflammation - 01 Feb 2017

Chersich MF, Takkinen J, Charlier C, Leclercq A, Adams PE, Godbole G, Altmeyer U, Friesema IH, Labbé Sandelin L, Jenkin L, Fontana L, Aldigeri R, Venter F, Luchters SM, Lecuit M, Cimino L

Link to Pubmed [PMID] – 28145786

Ocul. Immunol. Inflamm. 2017 Feb;:1-10

PURPOSE: Describe patient characteristics, treatment, and vision outcomes of Listeria monocytogenes endophthalmitis, an exceedingly rare form of listeriosis.

METHODS: L. monocytogenes endophthalmitis cases in human adults, located through Medline (32) and from disease surveillance centers (11). L. monocytogenes conjunctivitis and keratitis were excluded.

RESULTS: Most cases occurred in 2000-2015 (22/43), and almost all in Europe or North America (40/43). Patients were a median 61 years, 57% male (24/42) and half were immunosuppressed. Median days from entering care to diagnosis was 8 (IQR = 5-17). Only four were exogenous infections. L. monocytogenes was identified in 31/35 of anterior eye fluid samples (89%). Antibiotic regimens varied markedly (mostly ≥3 drugs). At diagnosis, most were blind in the affected eye (85%, 28/33), only a third regained normal vision (12/36). Older patients had poorer outcomes.

CONCLUSIONS: Cases increased over time. Diagnostic delays were common and visual impairment often refractory to treatment, especially in older adults. The condition’s rarity and variation in treatment makes it difficult to identify optimum therapy.

https://www.ncbi.nlm.nih.gov/pubmed/28145786