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© Research
Publication : Current opinion in immunology

Developmental programming of natural killer and innate lymphoid cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in immunology - 13 Mar 2013

Vosshenrich CA, Di Santo JP

Link to Pubmed [PMID] – 23490162

Curr. Opin. Immunol. 2013 Apr;25(2):130-8

In recent years we have witnessed a blooming interest in innate lymphoid cell (ILC) biology thanks to the discovery of novel lineages of ILC that are phenotypically and functionally distinct from NK cells. While the importance of these novel ILC subsets as essential functional components of the early immune responses are now clearly established, many questions remain as to how early ILC developmental fates are determined and how specific effector functions associated with individual ILC subsets are achieved. As the founding member of the ILC family, properties of NK cells have defining attributes that characterize this group of innate effectors. Analysing their developmental rules may provide clues to principles that guide ILC development in general.

http://www.ncbi.nlm.nih.gov/pubmed/23490162