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© Research
Publication : Scandinavian journal of infectious diseases

Efficacy, safety, and pharmacokinetics of once-daily boosted darunavir in pretreated HIV-infected patients

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Scandinavian journal of infectious diseases - 11 Mar 2013

Zucman D, De Truchis P, Peytavin G, Descamps D, Duvivier C, Tegna L, Weiss L, Delassus JL, Benalycherif A, Landman R

Link to Pubmed [PMID] – 23477545

Scand. J. Infect. Dis. 2013 May;45(5):407-10

OBJECTIVE AND METHODS: The efficacy and safety of switching to a combined regimen containing darunavir/ritonavir (DRV/r) was investigated in a retrospective study.

RESULTS: Sixty-six experienced patients receiving once-daily DRV/r (900/100 mg) in various regimens were included (median age 51 y; male 82%; Centers for Disease Control and Prevention (CDC) stages B or C 70%). The number of patients with plasma HIV RNA < 50 copies/ml increased from 71% (45/63) at baseline (before switch) to 84% (52/62) at visit 1 (weeks 3-11), and to 92% (60/65) at visit 2 (weeks 12-24). CD4 cells increased from 498 ± 201 cells/mm³ at baseline to 567 ± 232 cells/mm³ by visit 2. Good digestive and metabolic tolerance was observed. The median steady-state DRV plasma concentration, measured 24 ± 4 h after the last drug intake, was 1427 ng/ml. All DRV plasma concentrations were above the protein-binding corrected median effective concentration (EC₅₀) for the wild-type virus (55 ng/ml).

CONCLUSIONS: Once-daily DRV/r (900/100 mg) was efficacious in pretreated patients, with safe responses.

http://www.ncbi.nlm.nih.gov/pubmed/23477545