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© Christelle Durand
Microscopie d'un neurone. Le marquage jaune montre les synapses.
Publication : Neuroscience letters

Copper, manganese and zinc in the developing brain of control and quaking mice

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Neuroscience letters - 16 Dec 1987

Cloëz I, Bourre JM

Link to Pubmed [PMID] – 3441290

Neurosci. Lett. 1987 Dec;83(1-2):118-22

Copper, manganese and zinc were measured by flameless atomic absorption spectrophotometry in the developing brain of normal and quaking mice. The latter is a neurological mutant presenting early arrest of myelination. Copper concentration was increased by 200% between 10 and 20 days after birth and then leveled off in adult mice. Manganese concentration increased both in control mice and in quaking mice from 3 to 20 days by 200% and then decreased by 19% in control mice and 24% in quaking mice at adult age. Zinc increased by 93% in control and 173% in quaking mice between 10 and 20 days of age, and then progressively declined until 62 days. The mouse brain accumulates considerably all the 3 metals during early development. During the first 20 days, the augmentation is 6-fold for copper, 5-fold for manganese and 5.5-fold for zinc. In quaking, alterations are not very important.

http://www.ncbi.nlm.nih.gov/pubmed/3441290