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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : BioEssays : news and reviews in molecular, cellular and developmental biology

Clathrin-mediated endocytosis: what works for small, also works for big

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in BioEssays : news and reviews in molecular, cellular and developmental biology - 01 Jun 2010

Pizarro-Cerdá J, Bonazzi M, Cossart P

Link to Pubmed [PMID] – 20486136

Bioessays 2010 Jun;32(6):496-504

Clathrin and the endocytosis machinery has recently been described as being required in mammalian cells for the internalization of large particles including pathogenic bacteria, fungi, and large viruses. These apparently unexpected observations, within the framework of the classical mechanisms for the formation of clathrin-coated vesicles, are now considered as examples of a new non-classical function of clathrin, which can promote the internalization of membrane domains associated to planar clathrin lattices. The role of actin downstream of clathrin seems to be critical for this still poorly characterized process. The historical frontier between endocytosis and phagocytosis is vanishing in the light of this new role for clathrin.

http://www.ncbi.nlm.nih.gov/pubmed/20486136