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© Therese Couderc, Marc Lecuit
Publication : Infection and immunity

Atypical Hemolytic Isolates Are Virulent, albeit Less than

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Infection and immunity - 25 Mar 2019

Moura A, Disson O, Lavina M, Thouvenot P, Huang L, Leclercq A, Fredriksson-Ahomaa M, Eshwar AK, Stephan R, Lecuit M

Link to Pubmed [PMID] – 30670551

Infect. Immun. 2019 04;87(4)

is considered a nonpathogenic species. Natural atypical hemolytic isolates have been reported but have not been characterized in detail. Here, we report the genomic and functional characterization of representative isolates from the two known natural hemolytic clades. Whole-genome sequencing confirmed the presence of pathogenicity islands (LIPI) characteristic of species. Functional assays showed that LIPI-1 and genes are transcribed, and the corresponding gene products are expressed and functional. Using and assays, we show that atypical hemolytic is virulent, can actively cross the intestinal epithelium, and spreads systemically to the liver and spleen, albeit to a lesser degree than the reference EGDe strain. Although human exposure to hemolytic is likely rare, these findings are important for food safety and public health. The presence of virulence traits in some clades supports the existence of a common virulent ancestor of and .

https://www.ncbi.nlm.nih.gov/pubmed/30670551