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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : Acta microbiologica Hungarica

A genetic approach to demonstrate the role of listeriolysin O in the virulence of Listeria monocytogenes

Team: Bacteria-Cell Interactions
Member: Pascale Cossart
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Acta microbiologica Hungarica - 01 Jan 1989

Mengaud J, Vicente MF, Chenevert J, Geoffroy C, Baquero F, Perez-Diaz JC, Cossart P

Link to Pubmed [PMID] – 2561037

Acta Microbiol. Hung. 1989;36(2-3):177-82

The locus of insertion of a transposon previously used to obtain a non-haemolytic avirulent mutant was identified: it is the structural gene encoding lisreriolysin O, the thiol-dependent haemolysin, now called hlyA. The gene was completely sequenced. The preliminary structural and functional study of the chromosomal region containing the gene indicates that hlyA belongs to a monocistronic transcriptional unit. If it is the case, the transposon insertion would have no major polar effect on downstream genes and would only affect hlyA expression. These results emphasize the importance of the haemolysin in the virulence of Listeria monocytogenes.