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2024Rocuronium-specific antibodies drive perioperative anaphylaxis but can also function as reversal agents in preclinical models., Sci Transl Med 2024 Sep; 16(764): eado4463.
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2024Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2., iScience 2024 Jul; 27(7): 110354.
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2024Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus., Cell 2024 Jun; (): .
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2024Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1., Eur J Med Chem 2024 Apr; 269(): 116308.
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2024Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress., mBio 2024 Mar; 15(3): e0019824.
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2024Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2., Biochem Biophys Res Commun.
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2023Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation., Nat Microbiol 2023 Sep; (): .
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2023New insight into flavivirus maturation from structure/function studies of the yellow fever virus envelope protein complex, mBio, In press, ⟨10.1128/mbio.00706-23⟩.
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2023Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs., Protein Sci 2023 Jun; (): e4703.
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2023The MksG nuclease is the executing part of the bacterial plasmid defense system MksBEFG., Nucleic Acids Res 2023 Apr; 51(7): 3288-3306.
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2023DNA-binding mechanism and evolution of replication protein A., Nat Commun 2023 Apr; 14(1): 2326.
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2023Structure, function, and evolution of the Orthobunyavirus membrane fusion glycoprotein., Cell Rep 2023 Mar; 42(3): 112142.
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2023The crystal structure of a simian Foamy Virus receptor binding domain provides clues about entry into host cells., Nat Commun 2023 Mar; 14(1): 1262.
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2023Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system., Structure 2023 Feb; 31(2): 152-165.e7.
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2023Trypanosoma brucei RRP44: a versatile enzyme for processing structured and non-structured RNA substrates, Nucleic Acids Res . 2023 Jan 11;51(1):380-395. doi: 10.1093/nar/gkac1199..
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2023Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity., Front Mol Biosci 2023 ; 10(): 1192621.
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2022FtsEX-independent control of RipA-mediated cell separation in Corynebacteriales., Proc Natl Acad Sci U S A 2022 Dec; 119(50): e2214599119.
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2022Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium., BMC Biol 2022 08; 20(1): 176.
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2022Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target., FEBS J 2022 Feb; (): .
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2022Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies., Science 2022 Jan; 375(6576): 104-109.
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2022Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins., Front Microbiol 2022 ; 13(): 829094.
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2021Integrative Study of the Structural and Dynamical Properties of a KirBac3.1 Mutant: Functional Implication of a Highly Conserved Tryptophan in the Transmembrane Domain., Int J Mol Sci 2021 Dec; 23(1): .
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2021The epitope arrangement on flavivirus particles contributes to Mab C10’s extraordinary neutralization breadth across Zika and dengue viruses., Cell 2021 Dec; 184(25): 6052-6066.e18.
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2021Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy., Protein Sci 2021 Nov; (): .
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2021Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling., PLoS Biol 2021 Sep; 19(9): e3001392.
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2021A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells., Adv Sci (Weinh) 2021 05; 8(9): 2003630.
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2021A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes, Science, 2021, 372 (6541), pp.516-520. ⟨10.1126/science.abe6494⟩.
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2021Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein., Sci Rep 2021 Jan; 11(1): 944.
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2020Crystal Structure of Isoform CBd of the Basic Phospholipase A2 Subunit of Crotoxin: Description of the Structural Framework of CB for Interaction with Protein Targets., Molecules 2020 Nov; 25(22): .
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2020Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners., J Mol Biol 2020 11; 432(22): 5920-5937.
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2020Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker., Proc. Natl. Acad. Sci. U.S.A. 2020 Jul; (): .
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2020PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients., J Clin Invest 2020 06; 130(6): 2872-2887.
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2020Essential dynamic interdependence of FtsZ and SepF for Z-ring and septum formation in Corynebacterium glutamicum., Nat Commun 2020 Apr; 11(1): 1641.
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2020Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis., Elife 2020 Feb; 9(): .
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2020Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein., Nat Commun 2020 01; 11(1): 596.
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2019High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur, Molecules 2019 Dec;24(24).
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2019Double autoinhibition mechanism of signal transduction ATPases with numerous domains (STAND) with a tetratricopeptide repeat sensor, Nucleic Acids Res. 2019 Apr;47(7):3795-3810.
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2019The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F binding protein with unknown function, J. Struct. Biol. 2019 May;206(2):216-224.
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2019Orthobunyavirus spike architecture and recognition by neutralizing antibodies., Nat Commun 2019 Feb; 10(1): 879.
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2019First-in-class allosteric inhibitors of bacterial IMPDHs, Eur J Med Chem 2019 Feb;167:124-132.
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2018Mercury(II) Binding to Metallothionein in Mytilus edulis revealed by High Energy-Resolution XANES Spectroscopy, Chemistry 2019 Jan;25(4):997-1009.
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2018Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography, PLoS Negl Trop Dis 2018 Oct;12(10):e0006853.
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2018An extracellular Leptospira interrogans leucine-rich repeat protein binds human E- and VE-cadherins, Cell. Microbiol. 2019 02;21(2):e12949.
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2018An extracellular Leptospira interrogans leucine‐rich repeat protein binds human E‐ and VE‐cadherins, Eshghi, A, Gaultney, RA, England, P, et al. An extracellular Leptospira interrogans leucine‐rich repeat protein binds human E‐ and VE‐cadherins. Cellular Microbiology. 2019; 21:e12949. .
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2018Evolutionary diversification of the HAP2 membrane insertion motifs to drive gamete fusion across eukaryotes, PLoS Biol. 2018 Aug;16(8):e2006357.
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2018Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance, J. Struct. Biol. 2018 Nov;204(2):165-171.
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2018Structural insights into the signalling mechanisms of two-component systems, Nat. Rev. Microbiol. 2018 Jul;.
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2018Structural snapshots along the reaction mechanism of the atypical poplar thioredoxin-like2.1, FEBS Lett. 2018 Feb;.
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2018Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops., J Virol 2018 Jan; 92(1): .
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2017OH1 from Orf Virus: A New Tyrosine Phosphatase that Displays Distinct Structural Features and Triple Substrate Specificity, J. Mol. Biol. 2017 09;429(18):2816-2824.
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2017Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope., Nat Commun 2017 May; 8(): 15411.
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2017Bulgecin A: The Key to a Broad-Spectrum Inhibitor That Targets Lytic Transglycosylases., Antibiotics (Basel) 2017 Feb; 6(1): .
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2016Insights into Brain Glycogen Metabolism: The Structure of Human Brain Glycogen Phosphorylase, J. Biol. Chem. 2016 Jul;.
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2016Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ., J Biol Chem 2016 08; 291(32): 16699-708.
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2016Structural basis for haem piracy from host haemopexin by Haemophilus influenzae, Nat Commun 2016 05;7:11590.
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2015Structural insights into the loss of penicillinase and the gain of ceftazidimase activities by OXA-145 β-lactamase in Pseudomonas aeruginosa, J. Antimicrob. Chemother. 2016 Feb;71(2):395-402.
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2015Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation, Acta Crystallogr. D Biol. Crystallogr. 2015 Sep;71(Pt 9):1890-9.
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2015Structural characterization of a novel subfamily of leucine-rich repeat proteins from the human pathogen Leptospira interrogans, Acta Crystallogr. D Biol. Crystallogr. 2015 Jun;71(Pt 6):1351-9.
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2015Insight into cofactor recognition in arylamine N-acetyltransferase enzymes: structure of Mesorhizobium loti arylamine N-acetyltransferase in complex with coenzyme A, Acta Crystallogr. D Biol. Crystallogr. 2015 Feb;71(Pt 2):266-73.
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2014Glutathionyl-hydroquinone reductases from poplar are plastidial proteins that deglutathionylate both reduced and oxidized glutathionylated quinones, FEBS Lett. 2015 Jan;589(1):37-44.
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2014Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition, Acta Crystallogr. D Biol. Crystallogr. 2014 Nov;70(Pt 11):3066-79.
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2014Structural and functional features of Crl proteins and identification of conserved surface residues required for interaction with the RpoS/σS subunit of RNA polymerase, Biochem. J. 2014 Oct;463(2):215-24.
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2014Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members., Acta Crystallogr D Biol Crystallogr 2014 Oct; 70(Pt 10): 2631-9.
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2014Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c., J Struct Biol 2014 Nov; 188(2): 156-64.
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2014A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase, Nat Commun 2014 Sep;5:4833.
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2014Structural and enzymatic insights into Lambda glutathione transferases from Populus trichocarpa, monomeric enzymes constituting an early divergent class specific to terrestrial plants, Biochem. J. 2014 Aug;462(1):39-52.
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2014Structural basis of eukaryotic cell-cell fusion, Cell 2014 Apr;157(2):407-19.
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2013Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation, Proc. Natl. Acad. Sci. U.S.A. 2014 Jan;111(3):966-71.
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2013Structural and functional characterization of an orphan ATP-binding cassette ATPase involved in manganese utilization and tolerance in Leptospira spp, J. Bacteriol. 2013 Dec;195(24):5583-91.
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2013Structural and biochemical characterization of an active arylamine N-acetyltransferase possessing a non-canonical Cys-His-Glu catalytic triad, J. Biol. Chem. 2013 Aug;288(31):22493-505.
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2012In the absence of thioredoxins, what are the reductants for peroxiredoxins in Thermotoga maritima?, Antioxid. Redox Signal. 2013 May;18(13):1613-22.
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2012Structural and functional characterization of VanG D-Ala:D-Ser ligase associated with vancomycin resistance in Enterococcus faecalis, J. Biol. Chem. 2012 Nov;287(45):37583-92.
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2012Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway, J. Pineal Res. 2013 Jan;54(1):46-57.
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2012Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis., FEBS Lett 2012 Jun; 586(11): 1606-11.
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2012Purification, crystallization and preliminary X-ray characterization of Bacillus cereus arylamine N-acetyltransferase 3 [(BACCR)NAT3], Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2012 Feb;68(Pt 2):196-8.
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2011Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death, Structure 2011 Oct;19(10):1518-24.
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2011Insights into the Rrf2 repressor family–the structure of CymR, the global cysteine regulator of Bacillus subtilis, FEBS J. 2011 Aug;278(15):2689-701.
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2009DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding, J. Mol. Biol. 2010 Jan;395(1):89-104.
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2009Recombinant plant gamma carbonic anhydrase homotrimers bind inorganic carbon, FEBS Lett. 2009 Nov;583(21):3425-30.
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2009Structural plasticity and catalysis regulation of a thermosensor histidine kinase, Proc. Natl. Acad. Sci. U.S.A. 2009 Sep;106(38):16185-90.
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2009Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis, Mol. Microbiol. 2009 Mar;71(5):1102-16.
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2008Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1, Proteins 2008 Jan;70(1):284-8.
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2007Overproduction, purification, crystallization and preliminary X-ray analysis of the peroxiredoxin domain of a larger natural hybrid protein from Thermotoga maritima, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2008 Jan;64(Pt 1):29-31.
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2007The crystal structure of Trypanosoma cruzi arginine kinase, Proteins 2007 Oct;69(1):209-12.
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2007The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria, Protein Sci. 2007 Sep;16(9):1896-904.
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2007Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives — a screening based on affinity for the UMP-CMP binding site, FEBS J. 2007 Jul;274(14):3704-14.
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2006The crystal structure of Rv0813c from Mycobacterium tuberculosis reveals a new family of fatty acid-binding protein-like proteins in bacteria, J. Bacteriol. 2007 Mar;189(5):1899-904.
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2006Three dimensional structure and implications for the catalytic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei, J. Mol. Biol. 2007 Feb;366(3):868-81.
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2006The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer., Protein Sci 2006 Jun; 15(6): 1489-93.
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2003Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism, J. Biol. Chem. 2003 Feb;278(7):4963-71.
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2002Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods, J Enzyme Inhib Med Chem 2002 Jun;17(3):167-74.
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2002The crystal structure of the mouse apoptosis-inducing factor AIF, Nat. Struct. Biol. 2002 Jun;9(6):442-6.