• 2024
  Dejoux A, Zhu Q, Ganneau C, Goff OR, Godon O, Lemaitre J, Relouzat F, Huetz F, Sokal A, Vandenberghe A, Pecalvel C, Hunault L, Derenne T, Gillis CM, Iannascoli B, Wang Y, Rose T, Mertens C, Nicaise-Roland P, , England P, Mahévas M, de Chaisemartin L, Le Grand R, Letscher H, Saul F, Pissis C, Haouz A, Reber LL, Chappert P, Jönsson F, Ebo DG, Millot GA, Bay S, Chollet-Martin S, Gouel-Chéron A, Bruhns P, Rocuronium-specific antibodies drive perioperative anaphylaxis but can also function as reversal agents in preclinical models., Sci Transl Med 2024 Sep; 16(764): eado4463.
• 2024
  Planchais C, Fernández I, Chalopin B, Bruel T, Rosenbaum P, Beretta M, Dimitrov JD, Conquet L, Donati F, Prot M, Porrot F, Planas D, Staropoli I, Guivel-Benhassine F, Baquero E, van der Werf S, Haouz A, Simon-Lorière E, Montagutelli X, Maillère B, Rey FA, Guardado-Calvo P, Nozach H, Schwartz O, Mouquet H, Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2., iScience 2024 Jul; 27(7): 110354.
• 2024
  Fernández I, Saunders N, Duquerroy S, Bolland WH, Arbabian A, Baquero E, Blanc C, Lafaye P, Haouz A, Buchrieser J, Schwartz O, Rey FA, Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus., Cell 2024 Jun; (): .
• 2024
  Legru A, Batista FA, Puszko AK, Bouillon A, Maurel M, Martinez M, Ejjoummany A, Ortega Varga L, Adler P, Méchaly A, Hadjadj M, Sosnowski P, Hopfgartner G, Alzari PM, Blondel A, Haouz A, Barale JC, Hernandez JF, Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1., Eur J Med Chem 2024 Apr; 269(): 116308.
• 2024
  Martinez M, Bouillon A, Brûlé S, Raynal B, Haouz A, Alzari PM, Barale J-C, Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress., mBio 2024 Mar; 15(3): e0019824.
• 2024
  Le Coadou L, Berthelet J, Mechaly AE, Michail C, Bui LC, Dairou J, Haouz A, Dupret JM, Rodrigues Lima F, Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2., Biochem Biophys Res Commun.
• 2023
  Martinez M, Petit J, Leyva A, Sogues A, Megrian D, Rodriguez A, Gaday Q, Ben Assaya M, Portela MM, Haouz A, Ducret A, Grangeasse C, Alzari PM, Durán R, Wehenkel AM, Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation., Nat Microbiol 2023 Sep; (): .
• 2023
  E. Crampon, E. Covernton, M. Vaney, M. Dellarole, S. Sommer, A. Sharma, Ahmed Haouz, Patrick England, J. Lepault, S. Duquerroy, F. Rey, Giovanna Barba-Spaeth, New insight into flavivirus maturation from structure/function studies of the yellow fever virus envelope protein complex, mBio, In press, ⟨10.1128/mbio.00706-23⟩.
• 2023
  Gedeon A, Ayoub N, Brûlé S, Raynal B, Karimova G, Gelin M, Mechaly A, Haouz A, Labesse G, Munier-Lehmann H, Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs., Protein Sci 2023 Jun; (): e4703.
• 2023
  Weiß M, Giacomelli G, Assaya MB, Grundt F, Haouz A, Peng F, Petrella S, Wehenkel AM, Bramkamp M, The MksG nuclease is the executing part of the bacterial plasmid defense system MksBEFG., Nucleic Acids Res 2023 Apr; 51(7): 3288-3306.
• 2023
  Madru C, Martínez-Carranza M, Laurent S, Alberti AC, Chevreuil M, Raynal B, Haouz A, Le Meur RA, Delarue M, Henneke G, Flament D, Krupovic M, Legrand P, Sauguet L, DNA-binding mechanism and evolution of replication protein A., Nat Commun 2023 Apr; 14(1): 2326.
• 2023
  Hellert J, Aebischer A, Haouz A, Guardado-Calvo P, Reiche S, Beer M, Rey FA, Structure, function, and evolution of the Orthobunyavirus membrane fusion glycoprotein., Cell Rep 2023 Mar; 42(3): 112142.
• 2023
  Fernández I, Dynesen LT, Coquin Y, Pederzoli R, Brun D, Haouz A, Gessain A, Rey FA, Buseyne F, Backovic M, The crystal structure of a simian Foamy Virus receptor binding domain provides clues about entry into host cells., Nat Commun 2023 Mar; 14(1): 1262.
• 2023
  Dazzoni R, Li Y, López-Castilla A, Brier S, Mechaly A, Cordier F, Haouz A, Nilges M, Francetic O, Bardiaux B, Izadi-Pruneyre N, Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system., Structure 2023 Feb; 31(2): 152-165.e7.
• 2023
  Giovanna Cesaro, Heloisa Tramontin da Soler, Eloise Pavāo Guerra-Slompo, Ahmed Haouz, Pierre Legrand, Nilson Ivo Tonin Zanchin and Beatriz Gomes Guimaraes, Trypanosoma brucei RRP44: a versatile enzyme for processing structured and non-structured RNA substrates, Nucleic Acids Res . 2023 Jan 11;51(1):380-395. doi: 10.1093/nar/gkac1199..
• 2023
  Genera M, Colcombet-Cazenave B, Croitoru A, Raynal B, Mechaly A, Caillet J, Haouz A, Wolff N, Caillet-Saguy C, Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity., Front Mol Biosci 2023 ; 10(): 1192621.
• 2022
  Gaday Q, Megrian D, Carloni G, Martinez M, Sokolova B, Ben Assaya M, Legrand P, Brûlé S, Haouz A, Wehenkel AM, Alzari PM, , FtsEX-independent control of RipA-mediated cell separation in Corynebacteriales., Proc Natl Acad Sci U S A 2022 Dec; 119(50): e2214599119.
• 2022
  Léger C, Pitard I, Sadi M, Carvalho N, Brier S, Mechaly A, Raoux-Barbot D, Davi M, Hoos S, Weber P, Vachette P, Durand D, Haouz A, Guijarro JI, Ladant D, Chenal A, , Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium., BMC Biol 2022 08; 20(1): 176.
• 2022
  Walter P, Mechaly A, Bous J, Haouz A, England P, Lai-Kee-Him J, Ancelin A, Hoos S, Baron B, Trapani S, Bron P, Labesse G, Munier-Lehmann H, , Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target., FEBS J 2022 Feb; (): .
• 2022
  Mishra AK, Hellert J, Freitas N, Guardado-Calvo P, Haouz A, Fels JM, Maurer DP, Abelson DM, Bornholdt ZA, Walker LM, Chandran K, Cosset FL, McLellan JS, Rey FA, Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies., Science 2022 Jan; 375(6576): 104-109.
• 2022
  Zhu Y, Alvarez F, Wolff N, Mechaly A, Brûlé S, Neitthoffer B, Etienne-Manneville S, Haouz A, Boëda B, Caillet-Saguy C, , Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins., Front Microbiol 2022 ; 13(): 829094.
• 2021
  Fagnen C, Bannwarth L, Oubella I, Zuniga D, Haouz A, Forest E, Scala R, Bendahhou S, De Zorzi R, Perahia D, Vénien-Bryan C, , Integrative Study of the Structural and Dynamical Properties of a KirBac3.1 Mutant: Functional Implication of a Highly Conserved Tryptophan in the Transmembrane Domain., Int J Mol Sci 2021 Dec; 23(1): .
• 2021
  Sharma A, Zhang X, Dejnirattisai W, Dai X, Gong D, Wongwiwat W, Duquerroy S, Rouvinski A, Vaney MC, Guardado-Calvo P, Haouz A, England P, Sun R, Zhou ZH, Mongkolsapaya J, Screaton GR, Rey FA, , The epitope arrangement on flavivirus particles contributes to Mab C10’s extraordinary neutralization breadth across Zika and dengue viruses., Cell 2021 Dec; 184(25): 6052-6066.e18.
• 2021
  Nian Q, Berthelet J, Parlato M, Mechaly AE, Liu R, Dupret JM, Cerf-Bensussan N, Haouz A, Rodrigues Lima F, , Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy., Protein Sci 2021 Nov; (): .
• 2021
  Light TP, Brun D, Guardado-Calvo P, Pederzoli R, Haouz A, Neipel F, Rey FA, Hristova K, Backovic M, , Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling., PLoS Biol 2021 Sep; 19(9): e3001392.
• 2021
  Voegele A, Sadi M, O'Brien DP, Gehan P, Raoux-Barbot D, Davi M, Hoos S, Brûlé S, Raynal B, Weber P, Mechaly A, Haouz A, Rodriguez N, Vachette P, Durand D, Brier S, Ladant D, Chenal A, , A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells., Adv Sci (Weinh) 2021 05; 8(9): 2003630.
• 2021
  Sleiman D, Garcia PS, Lagune M, Loc'h J, Haouz A, Taib N, Röthlisberger P, Gribaldo S, Marlière P, Kaminski PA, A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes, Science, 2021, 372 (6541), pp.516-520. ⟨10.1126/science.abe6494⟩.
• 2021
  Genera M, Quioc-Salomon B, Nourisson A, Colcombet-Cazenave B, Haouz A, Mechaly A, Matondo M, Duchateau M, König A, Windisch MP, Neuveut C, Wolff N, Caillet-Saguy C, , Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein., Sci Rep 2021 Jan; 11(1): 944.
• 2020
  Nemecz D, Ostrowski M, Ravatin M, Saul F, Faure G, , Crystal Structure of Isoform CBd of the Basic Phospholipase A2 Subunit of Crotoxin: Description of the Structural Framework of CB for Interaction with Protein Targets., Molecules 2020 Nov; 25(22): .
• 2020
  Zhu Y, Delhommel F, Cordier F, Lüchow S, Mechaly A, Colcombet-Cazenave B, Girault V, Pepermans E, Bahloul A, Gautier C, Brûlé S, Raynal B, Hoos S, Haouz A, Caillet-Saguy C, Ivarsson Y, Wolff N, , Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners., J Mol Biol 2020 11; 432(22): 5920-5937.
• 2020
  Cheung YW, Röthlisberger P, Mechaly AE, Weber P, Levi-Acobas F, Lo Y, Wong AWC, Kinghorn AB, Haouz A, Savage GP, Hollenstein M*, Tanner JA*, , Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker., Proc. Natl. Acad. Sci. U.S.A. 2020 Jul; (): .
• 2020
  Pothlichet J, Rose T, Bugault F, Jeammet L, Meola A, Haouz A, Saul F, Geny D, Alcami J, Ruiz-Mateos E, Teyton L, Lambeau G, Thèze J, , PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients., J Clin Invest 2020 06; 130(6): 2872-2887.
• 2020
  Sogues A, Martinez M, Gaday Q, Ben Assaya M, Graña M, Voegele A, VanNieuwenhze M, England P, Haouz A, Chenal A, Trépout S, Duran R, Wehenkel AM, Alzari PM, , Essential dynamic interdependence of FtsZ and SepF for Z-ring and septum formation in Corynebacterium glutamicum., Nat Commun 2020 Apr; 11(1): 1641.
• 2020
  Williams AH, Wheeler R, Deghmane AE, Santecchia I, Schaub RE, Hicham S, Moya Nilges M, Malosse C, Chamot-Rooke J, Haouz A, Dillard JP, Robins WP, Taha MK, Gomperts Boneca I, Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis., Elife 2020 Feb; 9(): .
• 2020
  Hellert J, Buchrieser J, Larrous F, Minola A, de Melo GD, Soriaga L, England P, Haouz A, Telenti A, Schwartz O, Corti D, Bourhy H, Rey FA, , Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein., Nat Commun 2020 01; 11(1): 596.
• 2019
  Weber P, Pissis C, Navaza R, Mechaly AE, Saul F, Alzari PM, Haouz A, High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur, Molecules 2019 Dec;24(24).
• 2019
  Lisa MN, Cvirkaite-Krupovic V, Richet E, André-Leroux G, Alzari PM, Haouz A, Danot O, Double autoinhibition mechanism of signal transduction ATPases with numerous domains (STAND) with a tetratricopeptide repeat sensor, Nucleic Acids Res. 2019 Apr;47(7):3795-3810.
• 2019
  Benini S, Haouz A, Proux F, Alzari P, Wilson K, The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F binding protein with unknown function, J. Struct. Biol. 2019 May;206(2):216-224.
• 2019
  Hellert J, Aebischer A, Wernike K, Haouz A, Brocchi E, Reiche S, Guardado-Calvo P, Beer M, Rey FA, , Orthobunyavirus spike architecture and recognition by neutralizing antibodies., Nat Commun 2019 Feb; 10(1): 879.
• 2019
  Alexandre T, Lupan A, Helynck O, Vichier-Guerre S, Dugué L, Gelin M, Haouz A, Labesse G, Munier-Lehmann H, First-in-class allosteric inhibitors of bacterial IMPDHs, Eur J Med Chem 2019 Feb;167:124-132.
• 2018
  Manceau A, Bustamante P, Haouz A, Bourdineaud JP, Gonzalez-Rey M, Lemouchi C, Gautier-Luneau I, Geertsen V, Barruet E, Rovezzi M, Glatzel P, Pin S, Mercury(II) Binding to Metallothionein in Mytilus edulis revealed by High Energy-Resolution XANES Spectroscopy, Chemistry 2019 Jan;25(4):997-1009.
• 2018
  Amaral PA, Autheman D, de Melo GD, Gouault N, Cupif JF, Goyard S, Dutra P, Coatnoan N, Cosson A, Monet D, Saul F, Haouz A, Uriac P, Blondel A, Minoprio P, Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography, PLoS Negl Trop Dis 2018 Oct;12(10):e0006853.
• 2018
  Eshghi A, Gaultney RA, England P, Brûlé S, Miras I, Sato H, Coburn J, Bellalou J, Moriarty TJ, Haouz A, Picardeau M, An extracellular Leptospira interrogans leucine-rich repeat protein binds human E- and VE-cadherins, Cell. Microbiol. 2019 02;21(2):e12949.
• 2018
  Azad Eshghi Robert A. Gaultney Patrick England Sébastien Brûlé Isabelle Miras Hiromi Sato Jenifer Coburn Jacques Bellalou Tara J. Moriarty Ahmed Haouz Mathieu Picardeau, An extracellular Leptospira interrogans leucine‐rich repeat protein binds human E‐ and VE‐cadherins, Eshghi, A, Gaultney, RA, England, P, et al. An extracellular Leptospira interrogans leucine‐rich repeat protein binds human E‐ and VE‐cadherins. Cellular Microbiology. 2019; 21:e12949. .
• 2018
  Fedry J, Forcina J, Legrand P, Péhau-Arnaudet G, Haouz A, Johnson M, Rey FA, Krey T, Evolutionary diversification of the HAP2 membrane insertion motifs to drive gamete fusion across eukaryotes, PLoS Biol. 2018 Aug;16(8):e2006357.
• 2018
  Mechaly AE, Haouz A, Sassoon N, Buschiazzo A, Betton JM, Alzari PM, Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance, J. Struct. Biol. 2018 Nov;204(2):165-171.
• 2018
  Jacob-Dubuisson F, Mechaly A, Betton JM, Antoine R, Structural insights into the signalling mechanisms of two-component systems, Nat. Rev. Microbiol. 2018 Jul;.
• 2018
  Chibani K, Saul F, Didierjean C, Rouhier N, Haouz A, Structural snapshots along the reaction mechanism of the atypical poplar thioredoxin-like2.1, FEBS Lett. 2018 Feb;.
• 2018
  Vallbracht M, Brun D, Tassinari M, Vaney MC, Pehau-Arnaudet G, Guardado-Calvo P, Haouz A, Klupp BG, Mettenleiter TC, Rey FA, Backovic M, , Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops., J Virol 2018 Jan; 92(1): .
• 2017
  Segovia D, Haouz A, Porley D, Olivero N, Martínez M, Mariadassou M, Berois M, André-Leroux G, Villarino A, OH1 from Orf Virus: A New Tyrosine Phosphatase that Displays Distinct Structural Features and Triple Substrate Specificity, J. Mol. Biol. 2017 09;429(18):2816-2824.
• 2017
  Rouvinski A, Dejnirattisai W, Guardado-Calvo P, Vaney MC, Sharma A, Duquerroy S, Supasa P, Wongwiwat W, Haouz A, Barba-Spaeth G, Mongkolsapaya J, Rey FA, Screaton GR, , Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope., Nat Commun 2017 May; 8(): 15411.
• 2017
  Williams AH, Wheeler R, Thiriau C, Haouz A, Taha MK, Boneca IG, , Bulgecin A: The Key to a Broad-Spectrum Inhibitor  That Targets Lytic Transglycosylases., Antibiotics (Basel) 2017 Feb; 6(1): .
• 2016
  Mathieu C, Li de la Sierra-Gallay I, Duval R, Xu X, Cocaign A, Léger T, Woffendin G, Camadro JM, Etchebest C, Haouz A, Dupret JM, Rodrigues-Lima F, Insights into Brain Glycogen Metabolism: The Structure of Human Brain Glycogen Phosphorylase, J. Biol. Chem. 2016 Jul;.
• 2016
  Maisonneuve P, Caillet-Saguy C, Vaney MC, Bibi-Zainab E, Sawyer K, Raynal B, Haouz A, Delepierre M, Lafon M, Cordier F, Wolff N, , Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ., J Biol Chem 2016 08; 291(32): 16699-708.
• 2016
  Zambolin S, Clantin B, Chami M, Hoos S, Haouz A, Villeret V, Delepelaire P, Structural basis for haem piracy from host haemopexin by Haemophilus influenzae, Nat Commun 2016 05;7:11590.
• 2015
  Meziane-Cherif D, Bonnet R, Haouz A, Courvalin P, Structural insights into the loss of penicillinase and the gain of ceftazidimase activities by OXA-145 β-lactamase in Pseudomonas aeruginosa, J. Antimicrob. Chemother. 2016 Feb;71(2):395-402.
• 2015
  Labesse G, Alexandre T, Gelin M, Haouz A, Munier-Lehmann H, Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation, Acta Crystallogr. D Biol. Crystallogr. 2015 Sep;71(Pt 9):1890-9.
• 2015
  Miras I, Saul F, Nowakowski M, Weber P, Haouz A, Shepard W, Picardeau M, Structural characterization of a novel subfamily of leucine-rich repeat proteins from the human pathogen Leptospira interrogans, Acta Crystallogr. D Biol. Crystallogr. 2015 Jun;71(Pt 6):1351-9.
• 2015
  Xu X, Li de la Sierra-Gallay I, Kubiak X, Duval R, Chaffotte AF, Dupret JM, Haouz A, Rodrigues-Lima F, Insight into cofactor recognition in arylamine N-acetyltransferase enzymes: structure of Mesorhizobium loti arylamine N-acetyltransferase in complex with coenzyme A, Acta Crystallogr. D Biol. Crystallogr. 2015 Feb;71(Pt 2):266-73.
• 2014
  Lallement PA, Meux E, Gualberto JM, Dumarcay S, Favier F, Didierjean C, Saul F, Haouz A, Morel-Rouhier M, Gelhaye E, Rouhier N, Hecker A, Glutathionyl-hydroquinone reductases from poplar are plastidial proteins that deglutathionylate both reduced and oxidized glutathionylated quinones, FEBS Lett. 2015 Jan;589(1):37-44.
• 2014
  Cocaign A, Kubiak X, Xu X, Garnier G, Li de la Sierra-Gallay I, Chi-Bui L, Dairou J, Busi F, Abuhammad A, Haouz A, Dupret JM, Herrmann JL, Rodrigues-Lima F, Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition, Acta Crystallogr. D Biol. Crystallogr. 2014 Nov;70(Pt 11):3066-79.
• 2014
  Cavaliere P, Levi-Acobas F, Mayer C, Saul FA, England P, Weber P, Raynal B, Monteil V, Bellalou J, Haouz A, Norel F, Structural and functional features of Crl proteins and identification of conserved surface residues required for interaction with the RpoS/σS subunit of RNA polymerase, Biochem. J. 2014 Oct;463(2):215-24.
• 2014
  Williams AH, Veyrier FJ, Bonis M, Michaud Y, Raynal B, Taha MK, White SW, Haouz A, Boneca IG, , Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members., Acta Crystallogr D Biol Crystallogr 2014 Oct; 70(Pt 10): 2631-9.
• 2014
  Bellinzoni M, Haouz A, Miras I, Magnet S, André-Leroux G, Mukherjee R, Shepard W, Cole ST, Alzari PM, , Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c., J Struct Biol 2014 Nov; 188(2): 156-64.
• 2014
  Giganti D, Bouillon A, Tawk L, Robert F, Martinez M, Crublet E, Weber P, Girard-Blanc C, Petres S, Haouz A, Hernandez JF, Mercereau-Puijalon O, Alzari PM, Barale JC, A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase, Nat Commun 2014 Sep;5:4833.
• 2014
  Lallement PA, Meux E, Gualberto JM, Prosper P, Didierjean C, Saul F, Haouz A, Rouhier N, Hecker A, Structural and enzymatic insights into Lambda glutathione transferases from Populus trichocarpa, monomeric enzymes constituting an early divergent class specific to terrestrial plants, Biochem. J. 2014 Aug;462(1):39-52.
• 2014
  Amiable C, Paoletti J, Haouz A, Padilla A, Labesse G, Kaminski PA, Pochet S, 6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities, Eur J Med Chem 2014 Oct;85:418-37.
• 2014
  Pérez-Vargas J, Krey T, Valansi C, Avinoam O, Haouz A, Jamin M, Raveh-Barak H, Podbilewicz B, Rey FA, Structural basis of eukaryotic cell-cell fusion, Cell 2014 Apr;157(2):407-19.
• 2013
  Sauguet L, Shahsavar A, Poitevin F, Huon C, Menny A, Nemecz À, Haouz A, Changeux JP, Corringer PJ, Delarue M, Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation, Proc. Natl. Acad. Sci. U.S.A. 2014 Jan;111(3):966-71.
• 2013
  Benaroudj N, Saul F, Bellalou J, Miras I, Weber P, Bondet V, Murray GL, Adler B, Ristow P, Louvel H, Haouz A, Picardeau M, Structural and functional characterization of an orphan ATP-binding cassette ATPase involved in manganese utilization and tolerance in Leptospira spp, J. Bacteriol. 2013 Dec;195(24):5583-91.
• 2013
  Kubiak X, Li de la Sierra-Gallay I, Chaffotte AF, Pluvinage B, Weber P, Haouz A, Dupret JM, Rodrigues-Lima F, Structural and biochemical characterization of an active arylamine N-acetyltransferase possessing a non-canonical Cys-His-Glu catalytic triad, J. Biol. Chem. 2013 Aug;288(31):22493-505.
• 2012
  Couturier J, Prosper P, Winger AM, Hecker A, Hirasawa M, Knaff DB, Gans P, Jacquot JP, Navaza A, Haouz A, Rouhier N, In the absence of thioredoxins, what are the reductants for peroxiredoxins in Thermotoga maritima?, Antioxid. Redox Signal. 2013 May;18(13):1613-22.
• 2012
  Meziane-Cherif D, Saul FA, Haouz A, Courvalin P, Structural and functional characterization of VanG D-Ala:D-Ser ligase associated with vancomycin resistance in Enterococcus faecalis, J. Biol. Chem. 2012 Nov;287(45):37583-92.
• 2012
  Botros HG, Legrand P, Pagan C, Bondet V, Weber P, Ben-Abdallah M, Lemière N, Huguet G, Bellalou J, Maronde E, Beguin P, Haouz A, Shepard W, Bourgeron T, Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway, J. Pineal Res. 2013 Jan;54(1):46-57.
• 2012
  Mechaly AE, Haouz A, Miras I, Barilone N, Weber P, Shepard W, Alzari PM, Bellinzoni M, , Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis., FEBS Lett 2012 Jun; 586(11): 1606-11.
• 2012
  Kubiak X, Pluvinage B, Li de la Sierra-Gallay I, Weber P, Haouz A, Dupret JM, Rodrigues-Lima F, Purification, crystallization and preliminary X-ray characterization of Bacillus cereus arylamine N-acetyltransferase 3 [(BACCR)NAT3], Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2012 Feb;68(Pt 2):196-8.
• 2011
  Babault N, Cordier F, Lafage M, Cockburn J, Haouz A, Prehaud C, Rey FA, Delepierre M, Buc H, Lafon M, Wolff N, Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death, Structure 2011 Oct;19(10):1518-24.
• 2011
  Shepard W, Soutourina O, Courtois E, England P, Haouz A, Martin-Verstraete I, Insights into the Rrf2 repressor family–the structure of CymR, the global cysteine regulator of Bacillus subtilis, FEBS J. 2011 Aug;278(15):2689-701.
• 2010
  Meziane-Cherif D, Saul FA, Moubareck C, Weber P, Haouz A, Courvalin P, Périchon B, Molecular basis of vancomycin dependence in VanA-type Staphylococcus aureus VRSA-9, J. Bacteriol. 2010 Oct;192(20):5465-71.
• 2009
  Nury H, Bocquet N, Le Poupon C, Raynal B, Haouz A, Corringer PJ, Delarue M, Crystal structure of the extracellular domain of a bacterial ligand-gated ion channel, J. Mol. Biol. 2010 Feb;395(5):1114-27.
• 2009
  Grubisha O, Kaminska M, Duquerroy S, Fontan E, Cordier F, Haouz A, Raynal B, Chiaravalli J, Delepierre M, Israël A, Véron M, Agou F, DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding, J. Mol. Biol. 2010 Jan;395(1):89-104.
• 2009
  Martin V, Villarreal F, Miras I, Navaza A, Haouz A, González-Lebrero RM, Kaufman SB, Zabaleta E, Recombinant plant gamma carbonic anhydrase homotrimers bind inorganic carbon, FEBS Lett. 2009 Nov;583(21):3425-30.
• 2009
  Weber P, Meziane-Cherif D, Haouz A, Saul FA, Courvalin P, Crystallization and preliminary X-ray analysis of a D-Ala:D-Ser ligase associated with VanG-type vancomycin resistance, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2009 Oct;65(Pt 10):1024-6.
• 2009
  Albanesi D, Martín M, Trajtenberg F, Mansilla MC, Haouz A, Alzari PM, de Mendoza D, Buschiazzo A, Structural plasticity and catalysis regulation of a thermosensor histidine kinase, Proc. Natl. Acad. Sci. U.S.A. 2009 Sep;106(38):16185-90.
• 2009
  Sala C, Haouz A, Saul FA, Miras I, Rosenkrands I, Alzari PM, Cole ST, Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis, Mol. Microbiol. 2009 Mar;71(5):1102-16.
• 2008
  Ahmed F, André-Leroux G, Haouz A, Boutonnier A, Delepierre M, Qadri F, Nato F, Fournier JM, Alzari PM, Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1, Proteins 2008 Jan;70(1):284-8.
• 2007
  Barbey C, Rouhier N, Haouz A, Navaza A, Jacquot JP, Overproduction, purification, crystallization and preliminary X-ray analysis of the peroxiredoxin domain of a larger natural hybrid protein from Thermotoga maritima, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2008 Jan;64(Pt 1):29-31.
• 2007
  Fernandez P, Haouz A, Pereira CA, Aguilar C, Alzari PM, The crystal structure of Trypanosoma cruzi arginine kinase, Proteins 2007 Oct;69(1):209-12.
• 2007
  Graña M, Haouz A, Buschiazzo A, Miras I, Wehenkel A, Bondet V, Shepard W, Schaeffer F, Cole ST, Alzari PM, The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria, Protein Sci. 2007 Sep;16(9):1896-904.
• 2007
  Topalis D, Kumamoto H, Amaya Velasco MF, Dugué L, Haouz A, Alexandre JA, Gallois-Montbrun S, Alzari PM, Pochet S, Agrofoglio LA, Deville-Bonne D, Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives — a screening based on affinity for the UMP-CMP binding site, FEBS J. 2007 Jul;274(14):3704-14.
• 2006
  Shepard W, Haouz A, Graña M, Buschiazzo A, Betton JM, Cole ST, Alzari PM, The crystal structure of Rv0813c from Mycobacterium tuberculosis reveals a new family of fatty acid-binding protein-like proteins in bacteria, J. Bacteriol. 2007 Mar;189(5):1899-904.
• 2006
  Delarue M, Duclert-Savatier N, Miclet E, Haouz A, Giganti D, Ouazzani J, Lopez P, Nilges M, Stoven V, Three dimensional structure and implications for the catalytic mechanism of 6-phosphogluconolactonase from Trypanosoma brucei, J. Mol. Biol. 2007 Feb;366(3):868-81.
• 2006
  Bellinzoni M, Haouz A, Graña M, Munier-Lehmann H, Shepard W, Alzari PM, , The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer., Protein Sci 2006 Jun; 15(6): 1489-93.
• 2003
  Haouz A, Vanheusden V, Munier-Lehmann H, Froeyen M, Herdewijn P, Van Calenbergh S, Delarue M, Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism, J. Biol. Chem. 2003 Feb;278(7):4963-71.
• 2002
  Manallack DT, Pitt WR, Herdewijn P, Balzarini J, De Clercq E, Sanderson MR, Sohi M, Wien F, Munier-Lehmann H, Haouz A, Delarue M, Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods, J Enzyme Inhib Med Chem 2002 Jun;17(3):167-74.
• 2002
  Maté MJ, Ortiz-Lombardía M, Boitel B, Haouz A, Tello D, Susin SA, Penninger J, Kroemer G, Alzari PM, The crystal structure of the mouse apoptosis-inducing factor AIF, Nat. Struct. Biol. 2002 Jun;9(6):442-6.