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Guides
  • 2023
    Martinez M, Petit J, Leyva A, Sogues A, Megrian D, Rodriguez A, Gaday Q, Ben Assaya M, Portela MM, Haouz A, Ducret A, Grangeasse C, Alzari PM, Durán R, Wehenkel AM, Eukaryotic-like gephyrin and cognate membrane receptor coordinate corynebacterial cell division and polar elongation., Nat Microbiol 2023 Sep; (): .
  • 2023
    E. Crampon, E. Covernton, M. Vaney, M. Dellarole, S. Sommer, A. Sharma, Ahmed Haouz, Patrick England, J. Lepault, S. Duquerroy, F. Rey, Giovanna Barba-Spaeth, New insight into flavivirus maturation from structure/function studies of the yellow fever virus envelope protein complex, mBio, In press, ⟨10.1128/mbio.00706-23⟩.
  • 2023
    Yang L, Wagner T, Mechaly A, Boyko A, Bruch EM, Megrian D, Gubellini F, Alzari PM, Bellinzoni M, High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase., Nat Commun 2023 Aug; 14(1): 4851.
  • 2023
    Gedeon A, Ayoub N, Brûlé S, Raynal B, Karimova G, Gelin M, Mechaly A, Haouz A, Labesse G, Munier-Lehmann H, Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs., Protein Sci 2023 Jun; (): e4703.
  • 2023
    Weiß M, Giacomelli G, Assaya MB, Grundt F, Haouz A, Peng F, Petrella S, Wehenkel AM, Bramkamp M, The MksG nuclease is the executing part of the bacterial plasmid defense system MksBEFG., Nucleic Acids Res 2023 Apr; 51(7): 3288-3306.
  • 2023
    Madru C, Martínez-Carranza M, Laurent S, Alberti AC, Chevreuil M, Raynal B, Haouz A, Le Meur RA, Delarue M, Henneke G, Flament D, Krupovic M, Legrand P, Sauguet L, DNA-binding mechanism and evolution of replication protein A., Nat Commun 2023 Apr; 14(1): 2326.
  • 2023
    Hellert J, Aebischer A, Haouz A, Guardado-Calvo P, Reiche S, Beer M, Rey FA, Structure, function, and evolution of the Orthobunyavirus membrane fusion glycoprotein., Cell Rep 2023 Mar; 42(3): 112142.
  • 2023
    Fernández I, Dynesen LT, Coquin Y, Pederzoli R, Brun D, Haouz A, Gessain A, Rey FA, Buseyne F, Backovic M, The crystal structure of a simian Foamy Virus receptor binding domain provides clues about entry into host cells., Nat Commun 2023 Mar; 14(1): 1262.
  • 2023
    Dazzoni R, Li Y, López-Castilla A, Brier S, Mechaly A, Cordier F, Haouz A, Nilges M, Francetic O, Bardiaux B, Izadi-Pruneyre N, Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system., Structure 2023 Feb; 31(2): 152-165.e7.
  • 2023
    Covaleda-Cortés G, Mechaly A, Brissac T, Baehre H, Devaux L, England P, Raynal B, Hoos S, Gominet M, Firon A, Trieu-Cuot P, Kaminski PA, , The c-di-AMP-binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae., FEBS J 2023 Jan; (): .
  • 2023
    Giovanna Cesaro, Heloisa Tramontin da Soler, Eloise Pavāo Guerra-Slompo, Ahmed Haouz, Pierre Legrand, Nilson Ivo Tonin Zanchin and Beatriz Gomes Guimaraes, Trypanosoma brucei RRP44: a versatile enzyme for processing structured and non-structured RNA substrates, Nucleic Acids Res . 2023 Jan 11;51(1):380-395. doi: 10.1093/nar/gkac1199..
  • 2023
    Genera M, Colcombet-Cazenave B, Croitoru A, Raynal B, Mechaly A, Caillet J, Haouz A, Wolff N, Caillet-Saguy C, Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity., Front Mol Biosci 2023 ; 10(): 1192621.
  • 2022
    Gaday Q, Megrian D, Carloni G, Martinez M, Sokolova B, Ben Assaya M, Legrand P, Brûlé S, Haouz A, Wehenkel AM, Alzari PM, , FtsEX-independent control of RipA-mediated cell separation in Corynebacteriales., Proc Natl Acad Sci U S A 2022 Dec; 119(50): e2214599119.
  • 2022
    Léger C, Pitard I, Sadi M, Carvalho N, Brier S, Mechaly A, Raoux-Barbot D, Davi M, Hoos S, Weber P, Vachette P, Durand D, Haouz A, Guijarro JI, Ladant D, Chenal A, , Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium., BMC Biol 2022 08; 20(1): 176.
  • 2022
    Walter P, Mechaly A, Bous J, Haouz A, England P, Lai-Kee-Him J, Ancelin A, Hoos S, Baron B, Trapani S, Bron P, Labesse G, Munier-Lehmann H, , Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target., FEBS J 2022 Feb; (): .
  • 2022
    Akaash K. Mishra, Jan Hellert, Natalia Freitas, Pablo Guardado-Calvo, Ahmed Haouz, J. Maximilian Fels, Daniel P. Maurer, Dafna M. Abelson, Zachary A. Bornholdt, Laura M. Walker, Kartik Chandran, François-Loïc Cosset, Jason S. McLellan, Felix A. Rey, Structural basis of synergistic neutralization of Crimean-Congo hemorrhagic fever virus by human antibodies, Mishra et al., Science 375, 104–109 (2022).
  • 2022
    Zhu Y, Alvarez F, Wolff N, Mechaly A, Brûlé S, Neitthoffer B, Etienne-Manneville S, Haouz A, Boëda B, Caillet-Saguy C, , Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins., Front Microbiol 2022 ; 13(): 829094.
  • 2021
    Fagnen C, Bannwarth L, Oubella I, Zuniga D, Haouz A, Forest E, Scala R, Bendahhou S, De Zorzi R, Perahia D, Vénien-Bryan C, , Integrative Study of the Structural and Dynamical Properties of a KirBac3.1 Mutant: Functional Implication of a Highly Conserved Tryptophan in the Transmembrane Domain., Int J Mol Sci 2021 Dec; 23(1): .
  • 2021
    Sharma A, Zhang X, Dejnirattisai W, Dai X, Gong D, Wongwiwat W, Duquerroy S, Rouvinski A, Vaney MC, Guardado-Calvo P, Haouz A, England P, Sun R, Zhou ZH, Mongkolsapaya J, Screaton GR, Rey FA, , The epitope arrangement on flavivirus particles contributes to Mab C10’s extraordinary neutralization breadth across Zika and dengue viruses., Cell 2021 Dec; 184(25): 6052-6066.e18.
  • 2021
    Nian Q, Berthelet J, Parlato M, Mechaly AE, Liu R, Dupret JM, Cerf-Bensussan N, Haouz A, Rodrigues Lima F, , Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy., Protein Sci 2021 Nov; (): .
  • 2021
    Light TP, Brun D, Guardado-Calvo P, Pederzoli R, Haouz A, Neipel F, Rey FA, Hristova K, Backovic M, , Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling., PLoS Biol 2021 Sep; 19(9): e3001392.
  • 2021
    Voegele A, Sadi M, O'Brien DP, Gehan P, Raoux-Barbot D, Davi M, Hoos S, Brûlé S, Raynal B, Weber P, Mechaly A, Haouz A, Rodriguez N, Vachette P, Durand D, Brier S, Ladant D, Chenal A, , A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells., Adv Sci (Weinh) 2021 05; 8(9): 2003630.
  • 2021
    Sleiman D, Garcia PS, Lagune M, Loc'h J, Haouz A, Taib N, Röthlisberger P, Gribaldo S, Marlière P, Kaminski PA, A third purine biosynthetic pathway encoded by aminoadenine-based viral DNA genomes., Science 2021 Apr; 372(6541): 516-520.
  • 2021
    Genera M, Quioc-Salomon B, Nourisson A, Colcombet-Cazenave B, Haouz A, Mechaly A, Matondo M, Duchateau M, König A, Windisch MP, Neuveut C, Wolff N, Caillet-Saguy C, , Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein., Sci Rep 2021 Jan; 11(1): 944.
  • 2020
    Nemecz D, Ostrowski M, Ravatin M, Saul F, Faure G, , Crystal Structure of Isoform CBd of the Basic Phospholipase A2 Subunit of Crotoxin: Description of the Structural Framework of CB for Interaction with Protein Targets., Molecules 2020 Nov; 25(22): .
  • 2020
    Zhu Y, Delhommel F, Cordier F, Lüchow S, Mechaly A, Colcombet-Cazenave B, Girault V, Pepermans E, Bahloul A, Gautier C, Brûlé S, Raynal B, Hoos S, Haouz A, Caillet-Saguy C, Ivarsson Y, Wolff N, , Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners., J Mol Biol 2020 11; 432(22): 5920-5937.
  • 2020
    Cheung YW, Röthlisberger P, Mechaly AE, Weber P, Levi-Acobas F, Lo Y, Wong AWC, Kinghorn AB, Haouz A, Savage GP, Hollenstein M*, Tanner JA*, , Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker., Proc. Natl. Acad. Sci. U.S.A. 2020 Jul; (): .
  • 2020
    Pothlichet J, Rose T, Bugault F, Jeammet L, Meola A, Haouz A, Saul F, Geny D, Alcami J, Ruiz-Mateos E, Teyton L, Lambeau G, Thèze J, , PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients., J Clin Invest 2020 06; 130(6): 2872-2887.
  • 2020
    Sogues A, Martinez M, Gaday Q, Ben Assaya M, Graña M, Voegele A, VanNieuwenhze M, England P, Haouz A, Chenal A, Trépout S, Duran R, Wehenkel AM, Alzari PM, , Essential dynamic interdependence of FtsZ and SepF for Z-ring and septum formation in Corynebacterium glutamicum., Nat Commun 2020 Apr; 11(1): 1641.
  • 2020
    Gibson KH, Trajtenberg F, Wunder EA, Brady MR, San Martin F, Mechaly A, Shang Z, Liu J, Picardeau M, Ko A, Buschiazzo A, Sindelar CV, , An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete., Elife 2020 Mar; 9(): .
  • 2020
    Williams AH, Wheeler R, Deghmane AE, Santecchia I, Schaub RE, Hicham S, Moya Nilges M, Malosse C, Chamot-Rooke J, Haouz A, Dillard JP, Robins WP, Taha MK, Gomperts Boneca I, , Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation in Neisseria meningitidis., Elife 2020 Feb; 9(): .
  • 2020
    Hellert J, Buchrieser J, Larrous F, Minola A, de Melo GD, Soriaga L, England P, Haouz A, Telenti A, Schwartz O, Corti D, Bourhy H, Rey FA, , Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein., Nat Commun 2020 01; 11(1): 596.
  • 2019
    Weber P, Pissis C, Navaza R, Mechaly AE, Saul F, Alzari PM, Haouz A, High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur, Molecules 2019 Dec;24(24).
  • 2019
    Grillová L, Oppelt J, Mikalová L, Nováková M, Giacani L, Niesnerová A, Noda AA, Mechaly AE, Pospíšilová P, Čejková D, Grange PA, Dupin N, Strnadel R, Chen M, Denham I, Arora N, Picardeau M, Weston C, Forsyth RA, Šmajs D, Directly Sequenced Genomes of Contemporary Strains of Syphilis Reveal Recombination-Driven Diversity in Genes Encoding Predicted Surface-Exposed Antigens, Front Microbiol 2019;10:1691.
  • 2019
    Genera M, Samson D, Raynal B, Haouz A, Baron B, Simenel C, Guerois R, Wolff N, Caillet-Saguy C, , Structural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein., Sci Rep 2019 05; 9(1): 7438.
  • 2019
    Lisa MN, Cvirkaite-Krupovic V, Richet E, André-Leroux G, Alzari PM, Haouz A, Danot O, Double autoinhibition mechanism of signal transduction ATPases with numerous domains (STAND) with a tetratricopeptide repeat sensor, Nucleic Acids Res. 2019 Apr;47(7):3795-3810.
  • 2019
    Benini S, Haouz A, Proux F, Alzari P, Wilson K, The crystal structure of Rv2991 from Mycobacterium tuberculosis: An F binding protein with unknown function, J. Struct. Biol. 2019 May;206(2):216-224.
  • 2019
    Hellert J, Aebischer A, Wernike K, Haouz A, Brocchi E, Reiche S, Guardado-Calvo P, Beer M, Rey FA, , Orthobunyavirus spike architecture and recognition by neutralizing antibodies., Nat Commun 2019 Feb; 10(1): 879.
  • 2019
    Alexandre T, Lupan A, Helynck O, Vichier-Guerre S, Dugué L, Gelin M, Haouz A, Labesse G, Munier-Lehmann H, First-in-class allosteric inhibitors of bacterial IMPDHs, Eur J Med Chem 2019 Feb;167:124-132.
  • 2018
    Manceau A, Bustamante P, Haouz A, Bourdineaud JP, Gonzalez-Rey M, Lemouchi C, Gautier-Luneau I, Geertsen V, Barruet E, Rovezzi M, Glatzel P, Pin S, Mercury(II) Binding to Metallothionein in Mytilus edulis revealed by High Energy-Resolution XANES Spectroscopy, Chemistry 2019 Jan;25(4):997-1009.
  • 2018
    Amaral PA, Autheman D, de Melo GD, Gouault N, Cupif JF, Goyard S, Dutra P, Coatnoan N, Cosson A, Monet D, Saul F, Haouz A, Uriac P, Blondel A, Minoprio P, Designed mono- and di-covalent inhibitors trap modeled functional motions for Trypanosoma cruzi proline racemase in crystallography, PLoS Negl Trop Dis 2018 Oct;12(10):e0006853.
  • 2018
    Mechaly AS, Tovar Bohórquez MO, Mechaly AE, Suku E, Pérez MR, Giorgetti A, Ortí G, Viñas J, Somoza GM, Evidence of Alternative Splicing as a Regulatory Mechanism for Kissr2 in Pejerrey Fish, Front Endocrinol (Lausanne) 2018;9:604.
  • 2018
    Eshghi A, Gaultney RA, England P, Brûlé S, Miras I, Sato H, Coburn J, Bellalou J, Moriarty TJ, Haouz A, Picardeau M, An extracellular Leptospira interrogans leucine-rich repeat protein binds human E- and VE-cadherins, Cell. Microbiol. 2019 02;21(2):e12949.
  • 2018
    Delhommel F, Cordier F, Saul F, Chataigner L, Haouz A, Wolff N, Structural plasticity of the HHD2 domain of whirlin, FEBS J. 2018 10;285(20):3738-3752.
  • 2018
    Fedry J, Forcina J, Legrand P, Péhau-Arnaudet G, Haouz A, Johnson M, Rey FA, Krey T, Evolutionary diversification of the HAP2 membrane insertion motifs to drive gamete fusion across eukaryotes, PLoS Biol. 2018 Aug;16(8):e2006357.
  • 2018
    Mechaly AE, Haouz A, Sassoon N, Buschiazzo A, Betton JM, Alzari PM, Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance, J. Struct. Biol. 2018 Nov;204(2):165-171.
  • 2018
    Jacob-Dubuisson F, Mechaly A, Betton JM, Antoine R, Structural insights into the signalling mechanisms of two-component systems, Nat. Rev. Microbiol. 2018 Jul;.
  • 2018
    Williams AH, Wheeler R, Rateau L, Malosse C, Chamot-Rooke J, Haouz A, Taha MK, Boneca IG, , A step-by-step in crystallo guide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase., J Biol Chem 2018 04; 293(16): 6000-6010.
  • 2018
    Adhikarla H, Wunder EA, Mechaly AE, Mehta S, Wang Z, Santos L, Bisht V, Diggle P, Murray G, Adler B, Lopez F, Townsend JP, Groisman E, Picardeau M, Buschiazzo A, Ko AI, Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic, Front Cell Infect Microbiol 2018;8:45.
  • 2018
    Chibani K, Saul F, Didierjean C, Rouhier N, Haouz A, Structural snapshots along the reaction mechanism of the atypical poplar thioredoxin-like2.1, FEBS Lett. 2018 Feb;.
  • 2018
    Kebouchi M, Saul F, Taher R, Landier A, Beaudeau B, Dubrac S, Weber P, Haouz A, Picardeau M, Benaroudj N, , Structure and function of the Leptospira interrogans peroxide stress regulator (PerR), an atypical PerR devoid of a structural metal-binding site., J Biol Chem 2018 01; 293(2): 497-509.
  • 2018
    Vallbracht M, Brun D, Tassinari M, Vaney MC, Pehau-Arnaudet G, Guardado-Calvo P, Haouz A, Klupp BG, Mettenleiter TC, Rey FA, Backovic M, , Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops., J Virol 2018 Jan; 92(1): .
  • 2017
    Imelio JA, Larrieux N, Mechaly AE, Trajtenberg F, Buschiazzo A, , Snapshots of the Signaling Complex DesK:DesR in Different Functional States Using Rational Mutagenesis and X-ray Crystallography., Bio Protoc 2017 Aug; 7(16): e2510.
  • 2017
    Vulliez-Le Normand B, Saul FA, Hoos S, Faber BW, Bentley GA, Cross-reactivity between apical membrane antgen 1 and rhoptry neck protein 2 in P. vivax and P. falciparum: A structural and binding study, PLoS ONE 2017;12(8):e0183198.
  • 2017
    Segovia D, Haouz A, Porley D, Olivero N, Martínez M, Mariadassou M, Berois M, André-Leroux G, Villarino A, OH1 from Orf Virus: A New Tyrosine Phosphatase that Displays Distinct Structural Features and Triple Substrate Specificity, J. Mol. Biol. 2017 09;429(18):2816-2824.
  • 2017
    Mechaly AE, Soto Diaz S, Sassoon N, Buschiazzo A, Betton JM, Alzari PM, Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase, Structure 2017 Jun;25(6):939-944.e3.
  • 2017
    Rouvinski A, Dejnirattisai W, Guardado-Calvo P, Vaney MC, Sharma A, Duquerroy S, Supasa P, Wongwiwat W, Haouz A, Barba-Spaeth G, Mongkolsapaya J, Rey FA, Screaton GR, , Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope., Nat Commun 2017 May; 8(): 15411.
  • 2017
    Williams AH, Wheeler R, Thiriau C, Haouz A, Taha MK, Boneca IG, , Bulgecin A: The Key to a Broad-Spectrum Inhibitor  That Targets Lytic Transglycosylases., Antibiotics (Basel) 2017 Feb; 6(1): .
  • 2017
    San Martin F, Mechaly AE, Larrieux N, Wunder EA, Ko AI, Picardeau M, Trajtenberg F, Buschiazzo A, Crystallization of FcpA from Leptospira, a novel flagellar protein that is essential for pathogenesis, Acta Crystallogr F Struct Biol Commun 2017 03;73(Pt 3):123-129.
  • 2016
    Trajtenberg F, Imelio JA, Machado MR, Larrieux N, Marti MA, Obal G, Mechaly AE, Buschiazzo A, Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action, Elife 2016 12;5.
  • 2016
    Mathieu C, Li de la Sierra-Gallay I, Duval R, Xu X, Cocaign A, Léger T, Woffendin G, Camadro JM, Etchebest C, Haouz A, Dupret JM, Rodrigues-Lima F, Insights into Brain Glycogen Metabolism: The Structure of Human Brain Glycogen Phosphorylase, J. Biol. Chem. 2016 Jul;.
  • 2016
    Barba-Spaeth G, Dejnirattisai W, Rouvinski A, Vaney MC, Medits I, Sharma A, Simon-Lorière E, Sakuntabhai A, Cao-Lormeau VM, Haouz A, England P, Stiasny K, Mongkolsapaya J, Heinz FX, Screaton GR, Rey FA, , Structural basis of potent Zika-dengue virus antibody cross-neutralization., Nature 2016 Aug; 536(7614): 48-53.
  • 2016
    Maisonneuve P, Caillet-Saguy C, Vaney MC, Bibi-Zainab E, Sawyer K, Raynal B, Haouz A, Delepierre M, Lafon M, Cordier F, Wolff N, , Molecular Basis of the Interaction of the Human Protein Tyrosine Phosphatase Non-receptor Type 4 (PTPN4) with the Mitogen-activated Protein Kinase p38γ., J Biol Chem 2016 08; 291(32): 16699-708.
  • 2016
    Faure G, Bakouh N, Lourdel S, Odolczyk N, Premchandar A, Servel N, Hatton A, Ostrowski MK, Xu H, Saul FA, Moquereau C, Bitam S, Pranke I, Planelles G, Teulon J, Herrmann H, Roldan A, Zielenkiewicz P, Dadlez M, Lukacs GL, Sermet-Gaudelus I, Ollero M, Corringer PJ, Edelman A, Rattlesnake Phospholipase A2 Increases CFTR-Chloride Channel Current and Corrects ∆F508CFTR Dysfunction: Impact in Cystic Fibrosis, J. Mol. Biol. 2016 Jul;428(14):2898-915.
  • 2016
    Zambolin S, Clantin B, Chami M, Hoos S, Haouz A, Villeret V, Delepelaire P, Structural basis for haem piracy from host haemopexin by Haemophilus influenzae, Nat Commun 2016 05;7:11590.
  • 2016
    Fouts DE, Matthias MA, Adhikarla H, Adler B, Amorim-Santos L, Berg DE, Bulach D, Buschiazzo A, Chang YF, Galloway RL, Haake DA, Haft DH, Hartskeerl R, Ko AI, Levett PN, Matsunaga J, Mechaly AE, Monk JM, Nascimento AL, Nelson KE, Palsson B, Peacock SJ, Picardeau M, Ricaldi JN, Thaipandungpanit J, Wunder EA, Yang XF, Zhang JJ, Vinetz JM, What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira, PLoS Negl Trop Dis 2016 Feb;10(2):e0004403.
  • 2016
    Goyffon M, Saul F, Faure G, [Relationships between venomous function and innate immune function], Biol Aujourdhui 2015;209(3):195-210.
  • 2015
    East A, Mechaly AE, Huysmans GHM, Bernarde C, Tello-Manigne D, Nadeau N, Pugsley AP, Buschiazzo A, Alzari PM, Bond PJ, Francetic O, Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis, Structure 2016 Jan;24(1):92-104.
  • 2015
    Meziane-Cherif D, Bonnet R, Haouz A, Courvalin P, Structural insights into the loss of penicillinase and the gain of ceftazidimase activities by OXA-145 β-lactamase in Pseudomonas aeruginosa, J. Antimicrob. Chemother. 2016 Feb;71(2):395-402.
  • 2015
    Labesse G, Alexandre T, Gelin M, Haouz A, Munier-Lehmann H, Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation, Acta Crystallogr. D Biol. Crystallogr. 2015 Sep;71(Pt 9):1890-9.
  • 2015
    Miras I, Saul F, Nowakowski M, Weber P, Haouz A, Shepard W, Picardeau M, Structural characterization of a novel subfamily of leucine-rich repeat proteins from the human pathogen Leptospira interrogans, Acta Crystallogr. D Biol. Crystallogr. 2015 Jun;71(Pt 6):1351-9.
  • 2015
    Vulliez-Le Normand B, Faber BW, Saul FA, van der Eijk M, Thomas AW, Singh B, Kocken CH, Bentley GA, Crystal structure of Plasmodium knowlesi apical membrane antigen 1 and its complex with an invasion-inhibitory monoclonal antibody, PLoS ONE 2015;10(4):e0123567.
  • 2015
    Faber BW, Abdul Kadir K, Rodriguez-Garcia R, Remarque EJ, Saul FA, Vulliez-Le Normand B, Bentley GA, Kocken CH, Singh B, Low levels of polymorphisms and no evidence for diversifying selection on the Plasmodium knowlesi Apical Membrane Antigen 1 gene, PLoS ONE 2015;10(4):e0124400.
  • 2015
    Rouvinski A, Guardado-Calvo P, Barba-Spaeth G, Duquerroy S, Vaney MC, Kikuti CM, Navarro Sanchez ME, Dejnirattisai W, Wongwiwat W, Haouz A, Girard-Blanc C, Petres S, Shepard WE, Desprès P, Arenzana-Seisdedos F, Dussart P, Mongkolsapaya J, Screaton GR, Rey FA, , Recognition determinants of broadly neutralizing human antibodies against dengue viruses., Nature 2015 Apr; 520(7545): 109-13.
  • 2015
    Xu X, Li de la Sierra-Gallay I, Kubiak X, Duval R, Chaffotte AF, Dupret JM, Haouz A, Rodrigues-Lima F, Insight into cofactor recognition in arylamine N-acetyltransferase enzymes: structure of Mesorhizobium loti arylamine N-acetyltransferase in complex with coenzyme A, Acta Crystallogr. D Biol. Crystallogr. 2015 Feb;71(Pt 2):266-73.
  • 2014
    Lallement PA, Meux E, Gualberto JM, Dumarcay S, Favier F, Didierjean C, Saul F, Haouz A, Morel-Rouhier M, Gelhaye E, Rouhier N, Hecker A, Glutathionyl-hydroquinone reductases from poplar are plastidial proteins that deglutathionylate both reduced and oxidized glutathionylated quinones, FEBS Lett. 2015 Jan;589(1):37-44.
  • 2014
    Trajtenberg F, Albanesi D, Ruétalo N, Botti H, Mechaly AE, Nieves M, Aguilar PS, Cybulski L, Larrieux N, de Mendoza D, Buschiazzo A, Allosteric activation of bacterial response regulators: the role of the cognate histidine kinase beyond phosphorylation, MBio 2014 Nov;5(6):e02105.
  • 2014
    Cocaign A, Kubiak X, Xu X, Garnier G, Li de la Sierra-Gallay I, Chi-Bui L, Dairou J, Busi F, Abuhammad A, Haouz A, Dupret JM, Herrmann JL, Rodrigues-Lima F, Structural and functional characterization of an arylamine N-acetyltransferase from the pathogen Mycobacterium abscessus: differences from other mycobacterial isoforms and implications for selective inhibition, Acta Crystallogr. D Biol. Crystallogr. 2014 Nov;70(Pt 11):3066-79.
  • 2014
    Cavaliere P, Levi-Acobas F, Mayer C, Saul FA, England P, Weber P, Raynal B, Monteil V, Bellalou J, Haouz A, Norel F, Structural and functional features of Crl proteins and identification of conserved surface residues required for interaction with the RpoS/σS subunit of RNA polymerase, Biochem. J. 2014 Oct;463(2):215-24.
  • 2014
    Williams AH, Veyrier FJ, Bonis M, Michaud Y, Raynal B, Taha MK, White SW, Haouz A, Boneca IG, , Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members., Acta Crystallogr D Biol Crystallogr 2014 Oct; 70(Pt 10): 2631-9.
  • 2014
    Bellinzoni M, Haouz A, Miras I, Magnet S, André-Leroux G, Mukherjee R, Shepard W, Cole ST, Alzari PM, , Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c., J Struct Biol 2014 Nov; 188(2): 156-64.
  • 2014
    Giganti D, Bouillon A, Tawk L, Robert F, Martinez M, Crublet E, Weber P, Girard-Blanc C, Petres S, Haouz A, Hernandez JF, Mercereau-Puijalon O, Alzari PM, Barale JC, A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase, Nat Commun 2014 Sep;5:4833.
  • 2014
    Lallement PA, Meux E, Gualberto JM, Prosper P, Didierjean C, Saul F, Haouz A, Rouhier N, Hecker A, Structural and enzymatic insights into Lambda glutathione transferases from Populus trichocarpa, monomeric enzymes constituting an early divergent class specific to terrestrial plants, Biochem. J. 2014 Aug;462(1):39-52.
  • 2014
    Amiable C, Paoletti J, Haouz A, Padilla A, Labesse G, Kaminski PA, Pochet S, 6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities, Eur J Med Chem 2014 Oct;85:418-37.
  • 2014
    Correa A, Pacheco S, Mechaly AE, Obal G, Béhar G, Mouratou B, Oppezzo P, Alzari PM, Pecorari F, Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins), PLoS ONE 2014;9(5):e97438.
  • 2014
    Pérez-Vargas J, Krey T, Valansi C, Avinoam O, Haouz A, Jamin M, Raveh-Barak H, Podbilewicz B, Rey FA, Structural basis of eukaryotic cell-cell fusion, Cell 2014 Apr;157(2):407-19.
  • 2014
    Mechaly AE, Sassoon N, Betton JM, Alzari PM, Segmental helical motions and dynamical asymmetry modulate histidine kinase autophosphorylation, PLoS Biol. 2014 Jan;12(1):e1001776.
  • 2013
    Benaroudj N, Saul F, Bellalou J, Miras I, Weber P, Bondet V, Murray GL, Adler B, Ristow P, Louvel H, Haouz A, Picardeau M, Structural and functional characterization of an orphan ATP-binding cassette ATPase involved in manganese utilization and tolerance in Leptospira spp, J. Bacteriol. 2013 Dec;195(24):5583-91.
  • 2013
    Kubiak X, Li de la Sierra-Gallay I, Chaffotte AF, Pluvinage B, Weber P, Haouz A, Dupret JM, Rodrigues-Lima F, Structural and biochemical characterization of an active arylamine N-acetyltransferase possessing a non-canonical Cys-His-Glu catalytic triad, J. Biol. Chem. 2013 Aug;288(31):22493-505.
  • 2012
    Couturier J, Prosper P, Winger AM, Hecker A, Hirasawa M, Knaff DB, Gans P, Jacquot JP, Navaza A, Haouz A, Rouhier N, In the absence of thioredoxins, what are the reductants for peroxiredoxins in Thermotoga maritima?, Antioxid. Redox Signal. 2013 May;18(13):1613-22.
  • 2012
    Meziane-Cherif D, Saul FA, Haouz A, Courvalin P, Structural and functional characterization of VanG D-Ala:D-Ser ligase associated with vancomycin resistance in Enterococcus faecalis, J. Biol. Chem. 2012 Nov;287(45):37583-92.
  • 2012
    Botros HG, Legrand P, Pagan C, Bondet V, Weber P, Ben-Abdallah M, Lemière N, Huguet G, Bellalou J, Maronde E, Beguin P, Haouz A, Shepard W, Bourgeron T, Crystal structure and functional mapping of human ASMT, the last enzyme of the melatonin synthesis pathway, J. Pineal Res. 2013 Jan;54(1):46-57.
  • 2012
    Vulliez-Le Normand B, Tonkin ML, Lamarque MH, Langer S, Hoos S, Roques M, Saul FA, Faber BW, Bentley GA, Boulanger MJ, Lebrun M, Structural and functional insights into the malaria parasite moving junction complex, PLoS Pathog. 2012;8(6):e1002755.
  • 2012
    Mechaly AE, Bellomio A, Morante K, Agirre J, Gil-Cartón D, Valle M, González-Mañas JM, Guérin DM, Pores of the toxin FraC assemble into 2D hexagonal clusters in both crystal structures and model membranes, J. Struct. Biol. 2012 Nov;180(2):312-7.
  • 2012
    Faure G, Saul F, Crystallographic characterization of functional sites of crotoxin and ammodytoxin, potent β-neurotoxins from Viperidae venom, Toxicon 2012 Sep;60(4):531-8.
  • 2012
    Mechaly AE, Haouz A, Miras I, Barilone N, Weber P, Shepard W, Alzari PM, Bellinzoni M, , Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis., FEBS Lett 2012 Jun; 586(11): 1606-11.
  • 2012
    Kubiak X, Pluvinage B, Li de la Sierra-Gallay I, Weber P, Haouz A, Dupret JM, Rodrigues-Lima F, Purification, crystallization and preliminary X-ray characterization of Bacillus cereus arylamine N-acetyltransferase 3 [(BACCR)NAT3], Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2012 Feb;68(Pt 2):196-8.
  • 2011
    Faure G, Saul F, Structural and Functional Characterization of Anticoagulant, FXa-binding Viperidae Snake Venom Phospholipases A2, Acta Chim Slov 2011 Dec;58(4):671-7.
  • 2011
    Babault N, Cordier F, Lafage M, Cockburn J, Haouz A, Prehaud C, Rey FA, Delepierre M, Buc H, Lafon M, Wolff N, Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death, Structure 2011 Oct;19(10):1518-24.
  • 2011
    Faure G, Xu H, Saul FA, Crystal structure of crotoxin reveals key residues involved in the stability and toxicity of this potent heterodimeric β-neurotoxin, J. Mol. Biol. 2011 Sep;412(2):176-91.
  • 2011
    Shepard W, Soutourina O, Courtois E, England P, Haouz A, Martin-Verstraete I, Insights into the Rrf2 repressor family–the structure of CymR, the global cysteine regulator of Bacillus subtilis, FEBS J. 2011 Aug;278(15):2689-701.
  • 2011
    Mechaly AE, Bellomio A, Gil-Cartón D, Morante K, Valle M, González-Mañas JM, Guérin DM, Structural insights into the oligomerization and architecture of eukaryotic membrane pore-forming toxins, Structure 2011 Feb;19(2):181-91.
  • 2010
    Manina G, Bellinzoni M, Pasca MR, Neres J, Milano A, Ribeiro AL, Buroni S, Skovierová H, Dianišková P, Mikušová K, Marák J, Makarov V, Giganti D, Haouz A, Lucarelli AP, Degiacomi G, Piazza A, Chiarelli LR, De Rossi E, Salina E, Cole ST, Alzari PM, Riccardi G, , Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance., Mol Microbiol 2010 Sep; 77(5): 1172-85.
  • 2010
    Meziane-Cherif D, Saul FA, Moubareck C, Weber P, Haouz A, Courvalin P, Périchon B, Molecular basis of vancomycin dependence in VanA-type Staphylococcus aureus VRSA-9, J. Bacteriol. 2010 Oct;192(20):5465-71.
  • 2010
    Graña M, Bellinzoni M, Bellalou J, Haouz A, Miras I, Buschiazzo A, Winter N, Alzari PM, , Crystal structure of Mycobacterium tuberculosis LppA, a lipoprotein confined to pathogenic mycobacteria., Proteins 2010 Feb; 78(3): 769-72.
  • 2009
    Saul FA, Prijatelj-Znidarsic P, Vulliez-le Normand B, Villette B, Raynal B, Pungercar J, Krizaj I, Faure G, Comparative structural studies of two natural isoforms of ammodytoxin, phospholipases A2 from Vipera ammodytes ammodytes which differ in neurotoxicity and anticoagulant activity, J. Struct. Biol. 2010 Mar;169(3):360-9.
  • 2009
    Grubisha O, Kaminska M, Duquerroy S, Fontan E, Cordier F, Haouz A, Raynal B, Chiaravalli J, Delepierre M, Israël A, Véron M, Agou F, DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding, J. Mol. Biol. 2010 Jan;395(1):89-104.
  • 2009
    Martin V, Villarreal F, Miras I, Navaza A, Haouz A, González-Lebrero RM, Kaufman SB, Zabaleta E, Recombinant plant gamma carbonic anhydrase homotrimers bind inorganic carbon, FEBS Lett. 2009 Nov;583(21):3425-30.
  • 2009
    Weber P, Meziane-Cherif D, Haouz A, Saul FA, Courvalin P, Crystallization and preliminary X-ray analysis of a D-Ala:D-Ser ligase associated with VanG-type vancomycin resistance, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2009 Oct;65(Pt 10):1024-6.
  • 2009
    Graña M, Bellinzoni M, Miras I, Fiez-Vandal C, Haouz A, Shepard W, Buschiazzo A, Alzari PM, , Structure of Mycobacterium tuberculosis Rv2714, a representative of a duplicated gene family in Actinobacteria., Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 Oct; 65(Pt 10): 972-7.
  • 2009
    Albanesi D, Martín M, Trajtenberg F, Mansilla MC, Haouz A, Alzari PM, de Mendoza D, Buschiazzo A, Structural plasticity and catalysis regulation of a thermosensor histidine kinase, Proc. Natl. Acad. Sci. U.S.A. 2009 Sep;106(38):16185-90.
  • 2009
    Theillet FX, Saul FA, Vulliez-Le Normand B, Hoos S, Felici F, Weintraub A, Mulard LA, Phalipon A, Delepierre M, Bentley GA, Structural mimicry of O-antigen by a peptide revealed in a complex with an antibody raised against Shigella flexneri serotype 2a, J. Mol. Biol. 2009 May;388(4):839-50.
  • 2009
    Mechaly AE, Bellomio A, Morante K, González-Mañas JM, Guérin DM, Crystallization and preliminary crystallographic analysis of fragaceatoxin C, a pore-forming toxin from the sea anemone Actinia fragacea, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2009 Apr;65(Pt 4):357-60.
  • 2009
    Sala C, Haouz A, Saul FA, Miras I, Rosenkrands I, Alzari PM, Cole ST, Genome-wide regulon and crystal structure of BlaI (Rv1846c) from Mycobacterium tuberculosis, Mol. Microbiol. 2009 Mar;71(5):1102-16.
  • 2008
    Vulliez-Le Normand B, Saul FA, Phalipon A, Bélot F, Guerreiro C, Mulard LA, Bentley GA, Structures of synthetic O-antigen fragments from serotype 2a Shigella flexneri in complex with a protective monoclonal antibody, Proc. Natl. Acad. Sci. U.S.A. 2008 Jul;105(29):9976-81.
  • 2008
    Agirre J, Mechaly A, Cabo-Bilbao A, Guérin DM, A plate holder for non-destructive testing of mesophase crystallization assays, Eur. Biophys. J. 2008 Jul;37(6):871-7.
  • 2008
    Ahmed F, André-Leroux G, Haouz A, Boutonnier A, Delepierre M, Qadri F, Nato F, Fournier JM, Alzari PM, Crystal structure of a monoclonal antibody directed against an antigenic determinant common to Ogawa and Inaba serotypes of Vibrio cholerae O1, Proteins 2008 Jan;70(1):284-8.
  • 2007
    Barbey C, Rouhier N, Haouz A, Navaza A, Jacquot JP, Overproduction, purification, crystallization and preliminary X-ray analysis of the peroxiredoxin domain of a larger natural hybrid protein from Thermotoga maritima, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2008 Jan;64(Pt 1):29-31.
  • 2007
    Fernandez P, Haouz A, Pereira CA, Aguilar C, Alzari PM, The crystal structure of Trypanosoma cruzi arginine kinase, Proteins 2007 Oct;69(1):209-12.
  • 2007
    Graña M, Haouz A, Buschiazzo A, Miras I, Wehenkel A, Bondet V, Shepard W, Schaeffer F, Cole ST, Alzari PM, The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria, Protein Sci. 2007 Sep;16(9):1896-904.
  • 2007
    Topalis D, Kumamoto H, Amaya Velasco MF, Dugué L, Haouz A, Alexandre JA, Gallois-Montbrun S, Alzari PM, Pochet S, Agrofoglio LA, Deville-Bonne D, Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives — a screening based on affinity for the UMP-CMP binding site, FEBS J. 2007 Jul;274(14):3704-14.
  • 2006
    Shepard W, Haouz A, Graña M, Buschiazzo A, Betton JM, Cole ST, Alzari PM, The crystal structure of Rv0813c from Mycobacterium tuberculosis reveals a new family of fatty acid-binding protein-like proteins in bacteria, J. Bacteriol. 2007 Mar;189(5):1899-904.
  • 2006
    Cabo-Bilbao A, Spinelli S, Sot B, Agirre J, Mechaly AE, Muga A, Guérin DM, Crystal structure of the temperature-sensitive and allosteric-defective chaperonin GroELE461K, J. Struct. Biol. 2006 Sep;155(3):482-92.
  • 2006
    Bellinzoni M, Haouz A, Graña M, Munier-Lehmann H, Shepard W, Alzari PM, , The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer., Protein Sci 2006 Jun; 15(6): 1489-93.
  • 2002
    Maté MJ, Ortiz-Lombardía M, Boitel B, Haouz A, Tello D, Susin SA, Penninger J, Kroemer G, Alzari PM, The crystal structure of the mouse apoptosis-inducing factor AIF, Nat. Struct. Biol. 2002 Jun;9(6):442-6.
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