• 2019
  A. Vigouroux, Cordier B., Aristov A., Oldewurtel E.R., Özbaykal G., Chaze T., Matondo M., Bikard D., van Teeffelen S., Cell-wall synthases contribute to bacterial cell-envelope integrity by actively repairing defects, biorRxiv 2019; 763508.
• 2019
  Depardieu F, Bikard D, Gene silencing with CRISPRi in bacteria and optimization of dCas9 expression levels, Methods 2019 Aug;.
• 2019
  Ramachandran G, Bikard D, Editing the microbiome the CRISPR way, Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2019 May;374(1772):20180103.
• 2019
  Bernheim A, Bikard D, Touchon M, Rocha EPC, A matter of background: DNA repair pathways as a possible cause for the sparse distribution of CRISPR-Cas systems in bacteria, Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2019 May;374(1772):20180088.
• 2018
  François Rousset, Lun Cui, Elise Siouve, Christophe Becavin, Florence Depardieu, David Bikard, Genome-wide CRISPR-dCas9 screens in E. coli identify essential genes and phage host factors, PLOS Genetics 14(11): e1007749..
• 2018
  Cui L, Vigouroux A, Rousset F, Varet H, Khanna V, Bikard D, A CRISPRi screen in E. coli reveals sequence-specific toxicity of dCas9, Nat Commun. 2018 May 15;9(1):1912. doi: 10.1038/s41467-018-04209-5.
• 2018
  Vigouroux A, Oldewurtel ER, Cui L, Bikard D and van Teeffelen S, Tuning dCas9’s ability to block transcription enables robust, noiseless knockdown of bacterial genes, Molecular Systems Biology (2018) 14, e7899.
• 2017
  Aude Bernheim, Alicia Calvo Villamanan, Clovis Basier, Lun Cui, Eduardo P. C. Rocha, Marie Touchon, David Bikard, Inhibition of NHEJ repair by type II-A CRISPR-Cas systems in bacteria, Nature Communications 8, 2094..
• 2017
  Garneau JR, Depardieu F, Fortier LC, Bikard D, Monot M, PhageTerm: a tool for fast and accurate determination of phage termini and packaging mechanism using next-generation sequencing data, Sci Rep 2017 Aug;7(1):8292.
• 2017
  David Bikard, Rodolphe Barrangou, Using CRISPR-Cas systems as antimicrobials, Current Opinion in Microbiology 2017, 37:155–160.
• 2017
  Loot C, Nivina A, Cury J, Escudero JA, Ducos-Galand M, Bikard D, Rocha EP, Mazel D, Differences in Integron Cassette Excision Dynamics Shape a Trade-Off between Evolvability and Genetic Capacitance, MBio 2017 Mar;8(2).
• 2017
  R Heler, AV Wright, M Vucelja, D Bikard, JA Doudna, LA Marraffini, Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response, Molecular Cell 65 (1), 168-175.
• 2016
  Depardieu F, Didier JP, Bernheim A, Sherlock A, Molina H, Duclos B, Bikard D, A Eukaryotic-like Serine/Threonine Kinase Protects Staphylococci against Phages, Cell Host Microbe 2016 Sep;.
• 2016
  Cui L, Bikard D, Consequences of Cas9 cleavage in the chromosome of Escherichia coli, Nucleic Acids Res. 2016 Apr;.
• 2015
  Heler R, Marraffini LA, Bikard D, Adapting to new threats: the generation of memory by CRISPR-Cas immune systems, Mol. Microbiol. 2014 Jul;93(1):1-9.
• 2015
  Heler R, Samai P, Modell JW, Weiner C, Goldberg GW, Bikard D, Marraffini LA, Cas9 specifies functional viral targets during CRISPR-Cas adaptation, Nature 2015 Mar;519(7542):199-202.
• 2014
  Bikard D, Euler CW, Jiang W, Nussenzweig PM, Goldberg GW, Duportet X, Fischetti VA, Marraffini LA, Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials, Nat. Biotechnol. 2014 Nov;32(11):1146-50.
• 2014
  Goldberg GW, Jiang W, Bikard D, Marraffini LA, Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting, Nature 2014 Oct;514(7524):633-7.
• 2013
  Loot C, Parissi V, Escudero JA, Amarir-Bouhram J, Bikard D, Mazel D, The integron integrase efficiently prevents the melting effect of Escherichia coli single-stranded DNA-binding protein on folded attC sites, J. Bacteriol. 2014 Feb;196(4):762-71.
• 2013
  Bikard D, Marraffini LA, Control of gene expression by CRISPR-Cas systems, F1000Prime Rep 2013;5:47.
• 2013
  Bikard D, Jiang W, Samai P, Hochschild A, Zhang F, Marraffini LA, Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system, Nucleic Acids Res. 2013 Aug;41(15):7429-37.
• 2013
  Jiang W, Bikard D, Cox D, Zhang F, Marraffini LA, RNA-guided editing of bacterial genomes using CRISPR-Cas systems, Nat. Biotechnol. 2013 Mar;31(3):233-9.
• 2013
  Bikard D, Mazel D, Shuffling of DNA cassettes in a synthetic integron, Methods Mol. Biol. 2013;1073:169-74.
• 2012
  Bikard D, Hatoum-Aslan A, Mucida D, Marraffini LA, CRISPR interference can prevent natural transformation and virulence acquisition during in vivo bacterial infection, Cell Host Microbe 2012 Aug;12(2):177-86.
• 2011
  Bikard D, Marraffini LA, Innate and adaptive immunity in bacteria: mechanisms of programmed genetic variation to fight bacteriophages, Curr. Opin. Immunol. 2012 Feb;24(1):15-20.
• 2010
  Bikard D, Loot C, Baharoglu Z, Mazel D, Folded DNA in action: hairpin formation and biological functions in prokaryotes, Microbiol. Mol. Biol. Rev. 2010 Dec;74(4):570-88.
• 2010
  Loot C, Bikard D, Rachlin A, Mazel D, Cellular pathways controlling integron cassette site folding, EMBO J. 2010 Aug;29(15):2623-34.
• 2010
  Bikard D, Julié-Galau S, Cambray G, Mazel D, The synthetic integron: an in vivo genetic shuffling device, Nucleic Acids Res. 2010 Aug;38(15):e153.
• 2009
  Bouvier M, Ducos-Galand M, Loot C, Bikard D, Mazel D, Structural features of single-stranded integron cassette attC sites and their role in strand selection, PLoS Genet. 2009 Sep;5(9):e1000632.
• 2008
  Bikard D, Képès F, , [First French team success during iGEM synthetic biology competition], Med Sci (Paris) 2008 May;24(5):541-4.