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Guides
  • 2022
    Silvestre A, Shintre SS, Rachidi N, , Released Parasite-Derived Kinases as Novel Targets for Antiparasitic Therapies., Front Cell Infect Microbiol 2022 ; 12(): 825458.
  • 2021
    Bazin MA, Cojean S, Pagniez F, Bernadat G, Cavé C, Ourliac-Garnier I, Nourrisson MR, Morgado C, Picot C, Leclercq O, Baratte B, Robert T, Späth GF, Rachidi N, Bach S, Loiseau PM, Le Pape P, Marchand P, , In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition., Eur J Med Chem 2021 Jan; 210(): 112956.
  • 2021
    Rachidi N, Knippschild U, Späth GF, , Dangerous Duplicity: The Dual Functions of Casein Kinase 1 in Parasite Biology and Host Subversion., Front Cell Infect Microbiol 2021 ; 11(): 655700.
  • 2021
    Smirlis D, Dingli F, Sabatet V, Roth A, Knippschild U, Loew D, Späth GF, Rachidi N, , Identification of the Host Substratome of Leishmania-Secreted Casein Kinase 1 Using a SILAC-Based Quantitative Mass Spectrometry Assay., Front Cell Dev Biol 2021 ; 9(): 800098.
  • 2020
    Smirlis D, Dingli F, Pescher P, Prina E, Loew D, Rachidi N, Späth GF, , SILAC-based quantitative proteomics reveals pleiotropic, phenotypic modulation in primary murine macrophages infected with the protozoan pathogen Leishmania donovani., J Proteomics 2020 02; 213(): 103617.
  • 2019
    Xu P, Ianes C, Gärtner F, Liu C, Burster T, Bakulev V, Rachidi N, Knippschild U, Bischof J, , Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D)., Gene 2019 Oct; 715(): 144005.
  • 2019
    Böhm T, Meng Z, Haas P, Henne-Bruns D, Rachidi N, Knippschild U, Bischof J, , The kinase domain of CK1δ can be phosphorylated by Chk1., Biosci Biotechnol Biochem 2019 Sep; 83(9): 1663-1675.
  • 2019
    Bryant JM, Baumgarten S, Glover L, Hutchinson S, Rachidi N, , CRISPR in Parasitology: Not Exactly Cut and Dried!, Trends Parasitol 2019 06; 35(6): 409-422.
  • 2019
    Hombach-Barrigah A, Bartsch K, Smirlis D, Rosenqvist H, MacDonald A, Dingli F, Loew D, Späth GF, Rachidi N, Wiese M, Clos J, , Leishmania donovani 90 kD Heat Shock Protein – Impact of Phosphosites on Parasite Fitness, Infectivity and Casein Kinase Affinity., Sci Rep 2019 03; 9(1): 5074.
  • 2017
    Martel D, Beneke T, Gluenz E, Späth GF, Rachidi N, , Characterisation of Casein Kinase 1.1 in Leishmania donovani Using the CRISPR Cas9 Toolkit., Biomed Res Int 2017 ; 2017(): 4635605.
  • 2017
    Lamotte S, Späth GF, Rachidi N, Prina E, , The enemy within: Targeting host-parasite interaction for antileishmanial drug discovery., PLoS Negl Trop Dis 2017 Jun; 11(6): e0005480.
  • 2016
    Drini S, Criscuolo A, Lechat P, Imamura H, Skalický T, Rachidi N, Lukeš J, Dujardin JC, Späth GF, , Species- and Strain-Specific Adaptation of the HSP70 Super Family in Pathogenic Trypanosomatids., Genome Biol Evol 2016 07; 8(6): 1980-95.
  • 2016
    Durieu E, Prina E, Leclercq O, Oumata N, Gaboriaud-Kolar N, Vougogiannopoulou K, Aulner N, Defontaine A, No JH, Ruchaud S, Skaltsounis AL, Galons H, Späth GF, Meijer L, Rachidi N, , From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity., Antimicrob Agents Chemother 2016 05; 60(5): 2822-33.
  • 2015
    Späth GF, Drini S, Rachidi N, , A touch of Zen: post-translational regulation of the Leishmania stress response., Cell Microbiol 2015 May; 17(5): 632-8.
  • 2014
    Cayla M, Rachidi N, Leclercq O, Schmidt-Arras D, Rosenqvist H, Wiese M, Späth GF, , Transgenic analysis of the Leishmania MAP kinase MPK10 reveals an auto-inhibitory mechanism crucial for stage-regulated activity and parasite viability., PLoS Pathog 2014 Sep; 10(9): e1004347.
  • 2014
    Dacher M, Morales MA, Pescher P, Leclercq O, Rachidi N, Prina E, Cayla M, Descoteaux A, Späth GF, , Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses., Mol Microbiol 2014 Jul; 93(1): 146-66.
  • 2014
    Makrantoni V, Corbishley SJ, Rachidi N, Morrice NA, Robinson DA, Stark MJ, , Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae., PLoS One 2014 ; 9(2): e89399.
  • 2014
    Rachidi N, Taly JF, Durieu E, Leclercq O, Aulner N, Prina E, Pescher P, Notredame C, Meijer L, Späth GF, , Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infection., Antimicrob Agents Chemother 2014 ; 58(3): 1501-15.
  • 2013
    Leclercq O, Bartho K, Duelsner E, von Kleist L, Gherardini PF, Palmeri A, Helmer-Citterich M, Baumgart S, Späth GF, , Enrichment of Leishmania donovani ATP-binding proteins using a staurosporine capture compound., J Proteomics 2013 Jun; 86(): 97-104.
  • 2012
    Foucher AL, Rachidi N, Gharbi S, Blisnick T, Bastin P, Pemberton IK, Späth GF, , Apoptotic marker expression in the absence of cell death in staurosporine-treated Leishmania donovani., Antimicrob Agents Chemother 2013 Mar; 57(3): 1252-61.
  • 2012
    Marhadour S, Marchand P, Pagniez F, Bazin MA, Picot C, Lozach O, Ruchaud S, Antoine M, Meijer L, Rachidi N, Le Pape P, , Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents., Eur J Med Chem 2012 Dec; 58(): 543-56.
  • 2012
    Horjales S, Schmidt-Arras D, Limardo RR, Leclercq O, Obal G, Prina E, Turjanski AG, Späth GF, Buschiazzo A, , The crystal structure of the MAP kinase LmaMPK10 from Leishmania major reveals parasite-specific features and regulatory mechanisms., Structure 2012 Oct; 20(10): 1649-60.
  • 2011
    Schmidt-Arras D, Leclercq O, Gherardini PF, Helmer-Citterich M, Faigle W, Loew D, Späth GF, , Adaptation of a 2D in-gel kinase assay to trace phosphotransferase activities in the human pathogen Leishmania donovani., J Proteomics 2011 Aug; 74(9): 1644-51.
  • 2010
    Yau WL, Blisnick T, Taly JF, Helmer-Citterich M, Schiene-Fischer C, Leclercq O, Li J, Schmidt-Arras D, Morales MA, Notredame C, Romo D, Bastin P, Späth GF, , Cyclosporin A treatment of Leishmania donovani reveals stage-specific functions of cyclophilins in parasite proliferation and viability., PLoS Negl Trop Dis 2010 Jun; 4(6): e729.
  • 2009
    Keating P, Rachidi N, Tanaka TU, Stark MJ, , Ipl1-dependent phosphorylation of Dam1 is reduced by tension applied on kinetochores., J Cell Sci 2009 Dec; 122(Pt 23): 4375-82.
  • 2008
    Jovanic T, Roche B, Attal-Bonnefoy G, Leclercq O, Rougeon F, , Ectopic expression of AID in a non-B cell line triggers A:T and G:C point mutations in non-replicating episomal vectors., PLoS One 2008 Jan; 3(1): e1480.
  • 2007
    King EM, Rachidi N, Morrice N, Hardwick KG, Stark MJ, , Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores., Genes Dev 2007 May; 21(10): 1163-8.
  • 2005
    Ptacek J, Devgan G, Michaud G, Zhu H, Zhu X, Fasolo J, Guo H, Jona G, Breitkreutz A, Sopko R, McCartney RR, Schmidt MC, Rachidi N, Lee SJ, Mah AS, Meng L, Stark MJ, Stern DF, De Virgilio C, Tyers M, Andrews B, Gerstein M, Schweitzer B, Predki PF, Snyder M, , Global analysis of protein phosphorylation in yeast., Nature 2005 Dec; 438(7068): 679-84.
  • 2002
    Tanaka TU, Rachidi N, Janke C, Pereira G, Galova M, Schiebel E, Stark MJ, Nasmyth K, , Evidence that the Ipl1-Sli15 (Aurora kinase-INCENP) complex promotes chromosome bi-orientation by altering kinetochore-spindle pole connections., Cell 2002 Feb; 108(3): 317-29.
  • 2000
    Rachidi N, Martinez MJ, Barre P, Blondin B, , Saccharomyces cerevisiae PAU genes are induced by anaerobiosis., Mol Microbiol 2000 Mar; 35(6): 1421-30.
  • 2000
    Rachidi N, Barre P, Blondin B, , Examination of the transcriptional specificity of an enological yeast. A pilot experiment on the chromosome-III right arm., Curr Genet 2000 Jan; 37(1): 1-11.
  • 1999
    Rachidi N, Barre P, Blondin B, , Multiple Ty-mediated chromosomal translocations lead to karyotype changes in a wine strain of Saccharomyces cerevisiae., Mol Gen Genet 1999 Jun; 261(4-5): 841-50.
  • 1997
    Bandell M, Ansanay V, Rachidi N, Dequin S, Lolkema JS, , Membrane potential-generating malate (MleP) and citrate (CitP) transporters of lactic acid bacteria are homologous proteins. Substrate specificity of the 2-hydroxycarboxylate transporter family., J Biol Chem 1997 Jul; 272(29): 18140-6.
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