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© Valérie Zeitoun
Stéthoscope. Centre Médical de l'Institut Pasteur (CMIP).
Project

Projet ABCESS2 :A multicentric randomized double-blind phase 3 trial evaluating the efficacy of a targeted antibiotherapy in Hurley stage 2 active Hidradenitis Suppurativa patients versus doxycycline

Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
03
Jul 2019
Status
Ongoing
Members
3
Structures
2

About

There is a strong unmet need in HS treatment. The pathophysiology of HS is most likely multifactorial, including genetic, immune and microbiological factors. Specific pathobionts in HS lesions have been identified by our team. Antibiotics are widely used to treat HS and clinical remission of the disease has been obtained prospectively in 14/17 Hurley stage 2 patients at the Institut Pasteur Medical Center with an optimized antibiotic strategy.

The objective is to demonstrate the superiority of a 3–week course of a ceftriaxone+metronidazole treatment followed by 3 weeks of a rifampin+moxifloxacin+metronidazole combination, then 6 weeks of rifampin+moxifloxacin (experimental treatment) over a 12-week course of doxycycline in patients with Hurley stage 2 HS at week 12 in a multicentric randomized double-blind phase 3 tria

Collaborators:

–              Hôpital Avicenne, Bobigny

–              CHU de Rouen

–              Hôpital Edouard Herriot, Lyon

–              Centre Médical de l’Institut Pasteur, Paris

–              Clinique Courlancy, Reims

–              Hopital de la Timone, Marseille

ICAREB, CCCRT, laboratoire de Microbiologie du CHU de Caen