About
Contactin-associated protein-like 2 (Caspr2) encephalitis is a rare Antibody (Ab)-mediated autoimmune encephalitides (AE). Caspr2-antibdies are associated with a spectrum of neurological core symptoms and signs. The mechanisms by which Caspr2-specific Abs mediate pathology and how Ab-mediated effector functions translate into clinical syndromes and disease progression are incompletely understood. In this project we aim to dissect the relationship between anti-CAspr2 antibody characteristics, disease progression and treatment responses.