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© Lydie Couturier , Institut Pasteur
Organes sensoriels en développement chez la drosophile
News

SEMINAR “How the molecular machinery of pluripotency controls Nodal expression during epiblast maturation”

Friday 2nd December — at 12.00 pm — Amphi J.Monod (Bât.66)

Invited Speaker :  Jérôme Collignon

jcollignon

From Institut Jacques Monod
Unit of Regulation of Cell-Fate Specification in the Mouse

Abstract : During early development, modulations in the expression of Nodal, a TGFb family member, determine the specification of embryonic and extra-embryonic cell identities. Use of an in vitro model of mouse epiblast maturation, relying on the differentiation of embryonic stem cells (ESCs), revealed that this process entails a shift in the regulation of Nodal expression from one enhancer to another, as it does for most of the genes that remain expressed during this process. In the case of Nodal, we found that the first enhancer, although not necessary for Nodal expression in differentiated ESCs, is required to activate the second enhancer and therefore controls this regulatory shift. I will present our progress in understanding the molecular bases of this mechanism.

Hosted by Sigolène Meilhac