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© Bruno Dupuy, Claire Morvan, Institut Pasteur
Cellules végétative et spores de Clostridioides difficile / Vegative cells and spores of Clostridioides difficile
News

Highlighted paper: “c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficile”, Oberkampf et al. Science Signalling; Sept 2022; Pathogenesis of Bacterial anaerobes Unit; Microbiology Dpt.

Team: Pathogenesis of Bacterial Anaerobes
Department of: Microbiology
Member: Marine Oberkampf De Dabrun
Member: Bruno Dupuy

c-di-AMP signaling is required for bile salt resistance, osmotolerance, and long-term host colonization by Clostridioides difficileIn their 

 

 

 

In their latest publication, Oberkampf et al. (Pathogenesis of microbial anaerobes Unit) investigated the role of the second messenger c-di-AMP in various homeostatic and stress responses in bacteria.

 

 

Oberkampf et al. have identified it as a mediator of osmotic stress and bile salt resistance in the opportunistic pathogen Clostridioides difficile, with additional roles in cell wall homeostasis and biofilm formation.

(based on Rounding out cyclic dinucleotide signaling in Clostridioides difficile: A role and a mechanism for c-di-AMP, E.B. Purcell, focus, Science Signalling)