Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Research

Bacteriophages can promote horizontal gene transfer in bacteria through generalized transduction, in which bacterial DNA, instead of viral DNA, is packaged into a virion. Traditionally, generalized transduction  is considered a mistake from the point of view of the bacteriophages, since transducing particles do not propagate the viral DNA. In this collaborative work with two other research groups, we provide evidence for the adaptive potential of generalized transduction for the bacteriophages themselves [1].

Using Staphylococcus aureus as an experimental organism and the computational model of microbial evolution developed in our group (eVIVALDI [2]), we show that in environments where the survival of bacteria depends on their fast adaptation, the eradication of bacterial hosts led to the eradication of non-transducing, or virulent, bacteriophages as well. On the other hand, temperate transducing bacteriophages provide a mechanism for the acquisition of an antibiotic resistance gene that led to the survival of their hosts and to their own survival as lysogens within the adapted hosts.

Our results suggest that generalized transduction is a mutualistic trait that has evolved in association with the lysogenic lifestyle of bacteriophages, both to their and their hosts’ benefit.

[1] https://doi.org/10.1371/journal.ppat.1007888 (2019)

[2] https://doi.org/10.1038/s41598-019-39773-3 (2019)