Wei Yu is utilizing next-generation sequencing technology to reveal the role of key repair factors in V(D)J recombination and translocation formation
Deciphering the Oncogenic Lesions and Pathways of B and T Cell Cancers
MECHANISMS OF DNA RECOMBINATION
DNA double-strand breaks (DSBs), although common, are extremely dangerous (Deriano and Roth, Annual Review of Genetics, 2013). Unlike most other DNA lesions, DSBs directly threaten genomic integrity by disrupting the physical continuity of […]
2006-2009 Master of Bioinformatics in SUN YAT-SEN UNIVERSITY (CHINA)
2009-2011 Research assistant in ZheJiang University (CHINA)
2011-2014 Ph.D student in Technische Universität Darmstadt (GERMANY)
2014-Now PostDoc in Institut Pasteur
2022SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination., Nat Commun 2022 Jun; 13(1): 3707.
2020Repair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ., Nat Commun 2020 Oct; 11(1): 5239.
2016Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination, Cell Rep. 2016 Sep 13;16(11):2967-79. doi: 10.1016/j.celrep.2016.08.069. Epub 2016 Sep 2..
2013UCHL1 Is a Putative Tumor Suppressor in Ovarian Cancer Cells and Contributes to Cisplatin Resistance, J Cancer. 2013; 4(8): 662–670..
2013Dynamic protein-protein interaction subnetworks of lung cancer in cases with smoking history, Chin J Cancer. 2013 Feb; 32(2): 84–90..
2012Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing-based approach, PLoS Genet 8(12): e1003065. doi:10.1371/journal.pgen.1003065.
2011Global Analysis of DNA Methylation by Methyl-Capture Sequencing Reveals Epigenetic Control of Cisplatin Resistance in Ovarian Cancer Cell, PLoS One. 2011; 6(12): e29450..
2011RNA-Seq Analyses Generate Comprehensive Transcriptomic Landscape and Reveal Complex Transcript Patterns in Hepatocellular Carcinoma, PLoS One. 2011; 6(10): e26168..
2011The SOX2 response program in glioblastoma multiforme: an integrated ChIP-seq, expression microarray, and microRNA analysis, BMC Genomics. 2011; 12: 11..
2010ChIP-seq and functional analysis of the SOX2 gene in colorectal cancers, OMICS. 2010 Aug;14(4):369-84. doi: 10.1089/omi.2010.0053..
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