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© Research
Member: Permanent Researcher

Vincenzo Di Bartolo

• Immunoregulation

Laboratory: Immunoregulation

About

I studied biology and biochemistry at the University of Pisa, Italy.
In 1995, I joined the Molecular Immunology Unit at the Institut Pasteur to study TCR signalling. I investigated the role and the regulation of protein tyrosine kinases ZAP-70 and Lck.
Since 2006, I am senior member of the Lymphocyte Cell Biology Unit. My research focuses on the mechanisms regulating the dynamics of signalling protein complexes at the immune synapse and on their impact on adaptive immune responses.

Projects

Project
Completed
7 Members

Projet de Recherche Clinique : Impact des mutations du gène APC (Adenomatous polyposis coli) dans les réponses immunes anti-tumorales

Andres Alcover (PI)

La polypose adénomateuse familiale est une maladie caractérisée par l’apparition dans l’intestin de nombreux polypes susceptibles d‘évoluer en cancer en l’absence de prise en charge. Il s’agit d’une maladie génétique rare, le plus souvent […]
Project
Completed
16 Members

CoSImmGEn-F : constitution d’une cohorte de sujets atteints de polypose adénomateuse familiale et porteurs d’une mutation du gène APC afin d’étudier le rôle de la génétique du système immunitaire et de l’environnement dans la maladie

Hélène Laude (PI)

Rationnel La polypose adénomateuse familiale se manifeste par l’apparition dans l’intestin de nombreuses excroissances dénommées polypes adénomateux et susceptibles d‘évoluer en cancers en l’absence de prise en charge. Il s’agit d’une maladie génétique, le […]
Project
Completed
10 Members

Think tank: Cancer

Ludovic Deriano (PI)

The malignant transformation of cells translates into a major worldwide health, social and economic burden. Efforts to define the etiology of cancer, along with the development of new therapeutic approaches to treat them, would […]
Project
Ongoing
4 Members

How the dynamics of signaling complexes at the immunological synapse controls T cell activation

Vincenzo Di Bartolo (PI)

 Signals generated by the engagement of the T cell antigen receptor are decoded and integrated by molecular complexes that form at the immunological synapse upon T cell receptor engagement. Assembly of these complexes, as […]
Project
Ongoing
11 Members

Cytoskeleton, immunological synapse and T cell activation: role of Ezrin and Adenomatous polyposis coli

Andres Alcover (PI)

Antigen recognition by the T cell receptor triggers extensive rearrangements of both the actin and microtubule cytoskeleton. Cytoskeleton changes condition in turn morphological changes and molecular reorganization at the immunological synapse (Figure). We have […]

Publications

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