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© Thierry Blisnick & Philippe Bastin, Institut Pasteur
Bloodstream Trypanosoma brucei cell
Scientific Fields
Diseases
Organisms
Applications
Technique

Projects

Project
Completed
3 Members

Mode of action of intraflagellar transport

Philippe Bastin (PI)

Cilia and flagella are found at the surface of most cells of the human body. Their malfunctioning results in ciliopathies, genetic diseases that affect 1 individual out of 400. Their construction relies on intraflagellar […]
Project
Completed
2 Members

Molecular bases for the role of IFT172 in ciliogenesis and in ciliopathy

Philippe Bastin (PI)

The cilium is an important organelle for motility and cellular signaling found on most mammalian cells and on single celled organisms such as the parasite Trypanosoma brucei. Cilia formation requires the process of Intraflagellar […]
Project
Ongoing
5 Members

Functional Analysis of novel centrosomal and basal body components of two human parasitic protozoa

Philippe Bastin (PI)

Centrosomes (Cs) are the main microtubule organizing centers of many eukaryotic cells with critical roles in cell division, polarity, signaling and structure. Centrioles can act as basal bodies (BB), nucleating microtubules to form cilia […]
Project
Not started
5 Members

Deciphering how cells write and read the tubulin code

Philippe Bastin (PI)

Microtubules are cytoskeletal elements that are central to cell life. Their primary components are tubulins and undergo various post-translational modifications acting as a tubulin code. Here, we wish to investigate a main modification called […]
Project
Ongoing
12 Members

Role of tubulin glutamylation in flagellum construction (TUBGLUFLA)

Philippe Bastin (PI)

Cilia and flagella are essential eukaryotic organelles composed of an evolutionary conserved structure of 9 doublet microtubules that are similar but not equivalent. We propose that a tubulin post-translational modification called glutamylation could act […]

CV

PARCOURS ET TITRES UNIVERSITAIRES

2014: Habilitation à Diriger les recherches. Université Paris 7 Diderot. Etude du rôle de la protéine RESA de Plasmodium falciparum dans le remodelage fonctionnel de la membrane de l’hématie infectée.

1995-1997: Post-Doc. Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, California, USA. Toxoplasma gondii moleculars genetics and differentiation. Direction : Professeur John Boothroyd.

1992 : Thèse de Doctorat (spécialité Immunologie) de l’Université Paris VII. Caractérisation et étude moléculaire des antigènes vaccinants de la fraction 100kDa de Plasmodium falciparum. Direction: Dr. Odile Mercereau-Puijalon.

ACTIVITES PROFESSIONNELLES

2014 :               Chargé de Recherche, Unité de Biologie Cellulaire des Trypanosomes, Institut Pasteur, France. Direction: Dr. Philippe Bastin.

1997-2013 :        Chargé de Recherche, Unité d’Immunologie Moléculaire des Parasites, Institut Pasteur, France. Direction: Dr. Odile Mercereau-Puijalon.

1995-1997 :       Postdoctoral fellow, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, USA. Direction: Prof. John Boothroyd.

1995 :              Chargé de Recherche, Unité d’Immunologie Moléculaire des Parasites, Institut Pasteur, France. Direction: Dr. Odile Mercereau-Puijalon.

1991-1994 :       Assistant, Unité de Parasitologie Expérimentale, Institut Pasteur, France. Direction: Prof. Luiz Pereira Da Silva.

1988-1990 :       Boursier de la Fondation Roux, Unité de Parasitologie Expérimentale, Institut Pasteur,  France. Direction: Prof. Luiz Pereira Da Silva.

1983-1985 :       VSNA, Institut Bolivien de Biologie d’Altitude (IBBA), La Paz, Bolivie. Direction: Dr. Philippe Desjeux.

Publications

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