Anna received her PhD in Genetics and Molecular Medicine from the University of Naples Federico II (Italy) in 2016. During her graduate work, she focused on the study of prion disease. In the Zurzolo lab, Anna is continuing to work on the mechanism of prions misfolding and trafficking. Her major interest, however, is the use of zebrafish as a developmental model to assess the existence and function of tunneling nanotubes in vivo. She likes to spend countless hours (especially at night) imaging TNTs using various microscopes (confocal , spinning disc, light-sheet, etc).
Prion-like proteins spreading in neurodegenerative diseases: role of Tunneling Nanotubes (TNTs)
Prion-like proteins spreading in neurodegenerative diseases (NDs): role of Tunneling Nanotubes (TNTs) NDs are protein conformational disorders linked to the propagation of protein misfolding in the brain in a prion-like manner. A seminal discovery […]
Unraveling the structure/function of TNTs in vitro and in vivo.
Unraveling the structure/function of TNTs in vitro and in vivo. While TNTs may be involved in cell-to-cell communication in many physiological processes as well as diseases, their physiological relevance is unclear as their existence […]
2022Tunneling nanotubes provide a route for SARS-CoV-2 spreading., Sci Adv 2022 Jul; 8(29): eabo0171.
2020Fine intercellular connections in development: TNTs, cytonemes, or intercellular bridges?, Cell Stress 2020 Jan; 4(2): 30-43.
2019Effect of tolytoxin on tunneling nanotube formation and function, Sci Rep 2019 Apr;9(1):5741.
2019Correlative cryo-electron microscopy reveals the structure of TNTs in neuronal cells, Nat Commun 2019 01;10(1):342.
2017Cell Biology of Prion Protein, Prog Mol Biol Transl Sci 2017;150:57-82.
2017Regulation of sub-compartmental targeting and folding properties of the Prion-like protein Shadoo, Sci Rep 2017 Jun;7(1):3731.
2016The 37/67 kDa laminin receptor (LR) inhibitor, NSC47924, affects 37/67 kDa LR cell surface localization and interaction with the cellular prion protein, Sci Rep 2016 Apr;6:24457.