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  • Associate Professor
  • Clinical Research Assistant
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  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
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  • Honorary President of the Departement
  • Labex Coordinator
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About

The objective of our group is to understand the function of complex biological systems and to characterize the molecular mechanisms by which such functions are achieved. Most biological systems – if not all – do not behave like solid rocks, but they are in fact dynamical objects that interconvert among several different conformational states. In many cases, a specific function is achieved by an interplay between structural and dynamical properties of the system. As a consequence, understanding the behaviour of biological systems requires the determination of a structural ensemble (A), defined by the structures of all the relevant states that these molecules can occupy, their populations, and the rates of interconversion among these states. This goal can be effectively achieved by using integrative approaches that combine experimental and computational techniques (B).

Our group is focused on the development of modeling approaches for integrative structural biology and their application to systems of outstanding biological importance. A recent field of application is the simultaneous determination of protein structure and dynamics by integrating cryo-electron microscopy data with other sources of theoretical and experimental information (C).

The group is also dedicated to the dissemination of the techniques developed via the PLUMED open-source software and to the promotion of reproducibility and good behaviors in biomolecular simulations via the PLUMED Consortium.

Relevant bibliography

Fundings

Partners

Publications

For a full list of publications of the head of the group, please have a look here.

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Contact

For more info and inquiries, please contact Dr. Bonomi (mbonomi@pasteur.fr).