I am a virologist with a special interest in the study of the fundamental mechanisms of virus multiplication and their links to human health. I have a dual medical and scientific background that allows me to address both the fundamental aspects of virology and medical issues. My research focuses on the study of the replication mechanisms of the respiratory syncytial virus (RSV). My team is particularly focused on the understanding of viral factories, membrane-free viral-induced compartments, which host the central steps of RSV multiplication; and on the study of the late phases of viral multiplication (from the transport of new viral genomes to the release of virions). I joined the Pasteur Institute in January 2023 with my team to continue our work on RSV and to bring my medical skills and expertise on RSV to the National Reference Center for Respiratory Infections (including influenza).
RSV virion release mechanisms
Release of free virions at the very end of the viral cycle requires membrane abscission. Several viruses hijack the ESCRT pathway to ensure their release but not RSV. We aim to uncover which pathways […]
RSV ribonucleoproteins export mechanisms
Replication of genomic RNA in viral factories leads to production of viral RNPs (genomic RNA encapsidated by N and associated with polymerase complex proteins). These RNPs have to gain the assembly/budding sites at or […]
Towards the elucidation of the morphogenesis, organization and functioning of respiratory syncytial virus factories
RSV infection induce the formation of cytoplasmic viral inclusions called IBs. We demonstrated that these IBs shelter viral RNA transcription and replication and can thus be considered as the viral factories. Moreover, we recently […]
RAMEIX épouse WELTI Marie-Anne
RPPS : 10100139756
Research ID – ORCID 0000-0002-5901-3856
PU-PH : Professor (Paris Saclay – UVSQ), with Attending Physician clinical duties (Hôpital Ambroise Paré APHP, Pr Gault).
Team-Leader in INSERM – Paris-Saclay Versailles St-Quentin University- U1173 and Pasteur Institute (M3P)
Medical coordinator in CNR des infections respiratoires, Pasteur Institute, Paris
HDR “habilitation to supervise research » (2018), Versailles St-Quentin University, France
PhD, Microbiology-Virology, Paris Diderot University, France (2008)
MD– Medical Biology, Paris Descartes University, France (2010)
National Attending physician habilitation (Clinical microbiology), France (2015)
Master 2, Microbiology option Virology, Paris Diderot University, France (2005)
Studies of Biology at Ecole Normale Supérieure Ulm, France (1996-2000)
Medical studies – Paris Descartes University (Paris 5) – Necker Enfants Malades, France (1994-2000)
2000-04 Residency Assistance Publique des Hôpitaux de Paris (AP-HP)
2004-05 Master 2 Institut Pasteur, GMVR unit (Master 2 Scholarship from ARS)
2005-08 PhD Institut Pasteur, GMVR unit (Scholarship from CMIT-Institut Pasteur)
2008-10 Residency Assistance Publique des Hôpitaux de Paris
2010-15 AHU– Post-Graduate Clinical Fellow Versailles Saint-Quentin University/Ambroise Paré Hospital APHP
2015-16 PHU– Post-Graduate Clinical Fellow Versailles Saint-Quentin University/Ambroise Paré Hospital APHP
2016-20 MCU-PH, Associate Professor, with Attending Physician clinical duties Paris-Saclay-Versailles Saint-Quentin University/Ambroise Paré Hospital AP-HP
Paris-Saclay, Versailles St Quentin University, DFGSM3 (medical L3) around 15h/year
Paris-Saclay, Versailles St Quentin University, Master 2 A2I 4h/year
Paris-Saclay, Versailles St Quentin University; in charge of a teaching unit of the M2 A2I UVSQ since 2016
Paris Cité University, Pasteur Insitute, Master 2 2h/year
Paris Cité University, Master 1 2h/year
Member (vice-director) of the Scientific Committee of UFR des Sciences de la Santé (Teaching and research unit of medical and biological sciences) – Versailles St-Quentin University
Member of the medical HDR commission of Paris-Saclay university
Assistant Scientific director of Graduates school Life Sciences Health, Paris Saclay University
- 2017 Subvention DIM1HEALTH (Region Ile de France) ; Project « ELUCIDER LES MECANISMES DU TRANSPORT INTRACELLULAIRE DU RSV »
- 2018 ATIP AVENIR INSERM Project: “From virus factories to the export of new virions: unravelling the mystery of the respiratory syncytial virus replication”
- 2020-2022 Subvention from fondation Simone and Cino Del Duca, Institut de France. Project “Deciphering the mechanisms of respiratory syncytial virus replication from viral factories to the export of new virions “.
- 2020 – 2021 Special call for projects from Versailles St-Quentin university. ” SEROCOV : Développement d’un test sérologique pour le SARS-CoV2 “.
- 2021-2025: ANR project: RSVFact “Towards the elucidation of the morphogenesis, organization and functioning of respiratory syncytial virus factories”. 3 partners : Galloux, Unité de Virologie et Immunologie Moléculaires, INRAe, Jouy-en-Josas ; Z. Gueroui DR2 CNRS, UMR8640-Ecole Normale Supérieure, Paris and my team.
- 2022-2023: Extension of ATIP-AVENIR Funding for 2 years.
2023Ribonucleoprotein transport in Negative Strand RNA viruses., Biol Cell 2023 Jan; 115(1): e2200059.
2022Respiratory Syncytial Virus Two-Step Infection Screen Reveals Inhibitors of Early and Late Life Cycle Stages., Antimicrob Agents Chemother 2022 Dec; 66(12): e0103222.
2022Retinoic Acid-Inducible Gene I Activation Inhibits Human Respiratory Syncytial Virus Replication in Mammalian Cells and in Mouse and Ferret Models of Infection., J Infect Dis 2022 Dec; 226(12): 2079-2088.
2022Respiratory syncytial virus ribonucleoproteins hijack microtubule Rab11 dependent transport for intracellular trafficking., PLoS Pathog 2022 Jul; 18(7): e1010619.
2022Sensitive visualization of SARS-CoV-2 RNA with CoronaFISH., Life Sci Alliance 2022 Apr; 5(4): .
2021Performance of 30 commercial SARS-CoV-2 serology assays in testing symptomatic COVID-19 patients., Eur J Clin Microbiol Infect Dis 2021 Oct; 40(10): 2235-2241.
2021Monocyte distribution width as a biomarker of resistance to corticosteroids in patients with sepsis: the MOCORSEP observational study., Intensive Care Med 2021 Oct; 47(10): 1161-1164.
2021Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection., PLoS Pathog 2021 Jul; 17(7): e1009789.
2021A condensate-hardening drug blocks RSV replication in vivo., Nature 2021 Jul; 595(7868): 596-599.
2021Molecular investigation of a RSV outbreak in a geriatric hospital., BMC Geriatr 2021 Feb; 21(1): 120.
+View full list of publications