I am a virologist with a special interest in the study of the fundamental mechanisms of virus multiplication and their links to human health. I have a dual medical and scientific background that allows me to address both the fundamental aspects of virology and medical issues. My research focuses on the study of the replication mechanisms of the respiratory syncytial virus (RSV). My team is particularly focused on the understanding of viral factories, membrane-free viral-induced compartments, which host the central steps of RSV multiplication; and on the study of the late phases of viral multiplication (from the transport of new viral genomes to the release of virions). I joined the Pasteur Institute in January 2023 with my team to continue our work on RSV and to bring my medical skills and expertise on RSV to the National Reference Center for Respiratory Infections (including influenza).
Projects
CV
RAMEIX épouse WELTI Marie-Anne
RPPS : 10100139756
Research ID – ORCID 0000-0002-5901-3856
Present position
PU-PH : Professor (Paris Saclay – UVSQ), with Attending Physician clinical duties (Hôpital Ambroise Paré APHP, Pr Gault).
Team-Leader in INSERM – Paris-Saclay Versailles St-Quentin University- U1173 and Pasteur Institute (M3P)
Medical coordinator in CNR des infections respiratoires, Pasteur Institute, Paris
Education
HDR “habilitation to supervise research » (2018), Versailles St-Quentin University, France
PhD, Microbiology-Virology, Paris Diderot University, France (2008)
MD– Medical Biology, Paris Descartes University, France (2010)
National Attending physician habilitation (Clinical microbiology), France (2015)
Master 2, Microbiology option Virology, Paris Diderot University, France (2005)
Studies of Biology at Ecole Normale Supérieure Ulm, France (1996-2000)
Medical studies – Paris Descartes University (Paris 5) – Necker Enfants Malades, France (1994-2000)
Previous positions
2000-04 Residency Assistance Publique des Hôpitaux de Paris (AP-HP)
2004-05 Master 2 Institut Pasteur, GMVR unit (Master 2 Scholarship from ARS)
2005-08 PhD Institut Pasteur, GMVR unit (Scholarship from CMIT-Institut Pasteur)
2008-10 Residency Assistance Publique des Hôpitaux de Paris
2010-15 AHU– Post-Graduate Clinical Fellow Versailles Saint-Quentin University/Ambroise Paré Hospital APHP
2015-16 PHU– Post-Graduate Clinical Fellow Versailles Saint-Quentin University/Ambroise Paré Hospital APHP
2016-20 MCU-PH, Associate Professor, with Attending Physician clinical duties Paris-Saclay-Versailles Saint-Quentin University/Ambroise Paré Hospital AP-HP
Teaching
Paris-Saclay, Versailles St Quentin University, DFGSM3 (medical L3) around 15h/year
Paris-Saclay, Versailles St Quentin University, Master 2 A2I 4h/year
Paris-Saclay, Versailles St Quentin University; in charge of a teaching unit of the M2 A2I UVSQ since 2016
Paris Cité University, Pasteur Insitute, Master 2 2h/year
Paris Cité University, Master 1 2h/year
Responsabilities
Member (vice-director) of the Scientific Committee of UFR des Sciences de la Santé (Teaching and research unit of medical and biological sciences) – Versailles St-Quentin University
Member of the medical HDR commission of Paris-Saclay university
Assistant Scientific director of Graduates school Life Sciences Health, Paris Saclay University
Major founding
- 2017 Subvention DIM1HEALTH (Region Ile de France) ; Project « ELUCIDER LES MECANISMES DU TRANSPORT INTRACELLULAIRE DU RSV »
- 2018 ATIP AVENIR INSERM Project: “From virus factories to the export of new virions: unravelling the mystery of the respiratory syncytial virus replication”
- 2020-2022 Subvention from fondation Simone and Cino Del Duca, Institut de France. Project “Deciphering the mechanisms of respiratory syncytial virus replication from viral factories to the export of new virions “.
- 2020 – 2021 Special call for projects from Versailles St-Quentin university. ” SEROCOV : Développement d’un test sérologique pour le SARS-CoV2 “.
- 2021-2025: ANR project: RSVFact “Towards the elucidation of the morphogenesis, organization and functioning of respiratory syncytial virus factories”. 3 partners : Galloux, Unité de Virologie et Immunologie Moléculaires, INRAe, Jouy-en-Josas ; Z. Gueroui DR2 CNRS, UMR8640-Ecole Normale Supérieure, Paris and my team.
- 2022-2023: Extension of ATIP-AVENIR Funding for 2 years.
Publications
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2025Preparedness, prevention and control related to zoonotic avian influenza., EFSA J 2025 Jan; 23(1): e9191.
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2025Monitoring SARS-CoV-2 variants with complementary surveillance systems: risk evaluation of the Omicron JN.1 variant in France, August 2023 to January 2024., Euro Surveill 2025 Jan; 30(1): .
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2024Performance of whole genome sequencing for respiratory syncytial virus: insights from the first external quality assessment, France, 2024., Clin Microbiol Infect 2024 Dec; (): .
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2024Antagonism of BST2/Tetherin, a new restriction factor of respiratory syncytial virus, requires the viral NS1 protein, PLoS Pathogens, 2024, 20 (11), pp.e1012687. ⟨10.1371/journal.ppat.1012687⟩.
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2024Effectiveness of XBB.1.5 Vaccines Against Symptomatic SARS-CoV-2 Infection in Older Adults During the JN.1 Lineage-Predominant Period, European VEBIS Primary Care Multicentre Study, 20 November 2023-1 March 2024., Influenza Other Respir Viruses 2024 Nov; 18(11): e70009.
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2024Genotypic and phenotypic characterisation of respiratory syncytial virus after nirsevimab breakthrough infections: a large, multicentre, observational, real-world study., Lancet Infect Dis 2024 Oct; (): .
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2024Effect of nirsevimab on hospitalisations for respiratory syncytial virus bronchiolitis in France, 2023-24: a modelling study., Lancet Child Adolesc Health 2024 Oct; 8(10): 721-729.
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2024Effectiveness of COVID-19 vaccines administered in the 2023 autumnal campaigns in Europe: Results from the VEBIS primary care test-negative design study, September 2023-January 2024., Vaccine 2024 Jul; 42(19): 3931-3937.
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2024Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor., Nat Commun 2024 Feb; 15(1): 1173.
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2024Filling two needs with one deed: a combinatory mucosal vaccine against influenza A virus and respiratory syncytial virus., Front Immunol 2024 ; 15(): 1376395.
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