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© Ce graphique présente, pour chaque date d'observation depuis 2018, le taux d'accès ouvert des publications scientifiques de l'Institut Pasteur, avec un DOI Crossref, parues durant l'année précédente.
Publication : European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Performance of 30 commercial SARS-CoV-2 serology assays in testing symptomatic COVID-19 patients.

Team: Molecular mechanisms of multiplication of Pneumoviruses M3P
Member: Marie-Anne Rameix-Welti
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 01 Oct 2021

Vauloup-Fellous C, Maylin S, Périllaud-Dubois C, Brichler S, Alloui C, Gordien E, Rameix-Welti MA, Gault E, Moreau F, Fourati S, Challine D, Pawlotsky JM, Houhou-Fidouh N, Damond F, Mackiewicz V, Charpentier C, Méritet JF, Rozenberg F, Podglajen I, Marot S, Petit H, Burrel S, Akhavan S, Leruez-Ville M, Avettand-Fenoel V, Fourgeaud J, Guilleminot T, Gardiennet E, Bonacorsi S, Carol A, Carcelain G, Villemonteix J, Boukli N, Gozlan J, Morand-Joubert L, Legoff J, Delaugerre C, Chaix ML, Roque-Afonso AM, Dortet L, Naas T, Ronat JB, Lepape S, Marcelin AG, Descamps D,

Link to Pubmed [PMID] – 33782783

Link to DOI – 10.1007/s10096-021-04232-3

Eur J Clin Microbiol Infect Dis 2021 Oct; 40(10): 2235-2241

We report evaluation of 30 assays’ (17 rapid tests (RDTs) and 13 automated/manual ELISA/CLIA assay (IAs)) clinical performances with 2594 sera collected from symptomatic patients with positive SARS-CoV-2 rRT-PCR on a respiratory sample, and 1996 pre-epidemic serum samples expected to be negative. Only 4 RDT and 3 IAs fitted both specificity (> 98%) and sensitivity (> 90%) criteria according to French recommendations. Serology may offer valuable information during COVID-19 pandemic, but inconsistent performances observed among the 30 commercial assays evaluated, which underlines the importance of independent evaluation before clinical implementation.