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  • Master Student
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  • Permanent Researcher
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  • PhD Student
  • Physician
  • Post-doc
  • Prize
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  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
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Scientific Fields
Diseases
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About

Maria Manich is a research Engineer at the Institut Pasteur, involved in studying the cell biology and biomechanics of Entamoeba histolytica, a pathogenic amoeba responsible for amoebiasis. Her work focuses on the organism’s cellular dynamics and how it interacts with the host’s tissue. She has contributed to multiple studies on the topic, including the mechanisms of cell motility and the cellular responses to mechanical stimuli within the human gut. Maria employs advanced imaging techniques and computational analysis to explore these interactions.

Projects

Project
Ongoing
5 Members

Call Emulate 2020 – Mucibiome – Impact of the colon mucus layer colonized by microbiota on the colonic epithelium mechanics under strech and on the pathogenesis of Entamoeba histolytica

Elisabeth Labruyère (PI)

In the human colon, mucus protects the underlying epithelium from pathogens. During infection, pathogens and resident microbiota compete for nutritional metabolites and therefore changes may alter the equilibrium in the colon ecosystem contributing to […]
Project
Ongoing
7 Members

PTR 232-2019. Mechabiome. Computational imaging of the spatiotemporal distribution of forces in gut tissue: a study of the cross talk between cell mechanics, microbiome and infectious processes

Elisabeth Labruyère (PI)

Mechanical forces trigger many cellular functions and change the geometry and physical properties of a tissue. Very few studies look at the biomechanisms of invasion of microbes at tissue level. – In this project […]
Project
Ongoing
6 Members

Impact of tissue components on cell migration: adhesion strength, cell morpho-dynamics and intracellular biophysics parameters.

Elisabeth Labruyère (PI)

We aim to analyze the impact of substrates on Entamoeba histolytica mode of migration during colonic mucosa invasion using live imaging and quantitative image analysis. E. histolytica, the etiological agent of amoebiasis, is a […]
Project
Completed
7 Members

Imaging and mathematical modelling of cell morphology and motility

(PI)

Elucidating the mechanisms underlying cell deformation and motility is a topic of major interest in cell biology, for they are strongly involved in cell development, immune responses, cancer and infectious diseases. This projects focuses on the […]

Publications

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