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Scientific Fields
Diseases
Organisms
Applications
Technique

About

Maria Manich is a research engineer involved in the study of the cell biology and biomechanics of Entamoeba histolytica, a pathogenic amoeba responsible for amoebiasis. Her work focuses on the cellular dynamics of the organism and how it interacts with host tissues. She has contributed to several studies on the subject, notably on the mechanisms of cell motility and cellular responses to mechanical stimuli in the human intestine. Maria uses advanced imaging techniques and computational analysis to explore these interactions.
Recently, she has been participating in deciphering the neuronal code of Hydra vulgaris, a small freshwater cnidarian.

Projects

Project
Ongoing
5 Members

DECODE: Chasing functional ensembles in calcium imaging of Hydra’s neuronal activity to decode its behaviours’ repertoire

Thibault Lagache (PI)

The overall objective of this project is to develop a mathematical framework to bridge the gap between single neuron imaging in vivo and the emergent computational properties of neuronal ensembles that encode animal’s behaviors. […]
Project
Ongoing
5 Members

Call Emulate 2020 – Mucibiome – Impact of the colon mucus layer colonized by microbiota on the colonic epithelium mechanics under strech and on the pathogenesis of Entamoeba histolytica

Elisabeth Labruyère (PI)

In the human colon, mucus protects the underlying epithelium from pathogens. During infection, pathogens and resident microbiota compete for nutritional metabolites and therefore changes may alter the equilibrium in the colon ecosystem contributing to […]
Project
Ongoing
7 Members

PTR 232-2019. Mechabiome. Computational imaging of the spatiotemporal distribution of forces in gut tissue: a study of the cross talk between cell mechanics, microbiome and infectious processes

Elisabeth Labruyère (PI)

Mechanical forces trigger many cellular functions and change the geometry and physical properties of a tissue. Very few studies look at the biomechanisms of invasion of microbes at tissue level. – In this project […]
Project
Ongoing
6 Members

Impact of tissue components on cell migration: adhesion strength, cell morpho-dynamics and intracellular biophysics parameters.

Elisabeth Labruyère (PI)

We aim to analyze the impact of substrates on Entamoeba histolytica mode of migration during colonic mucosa invasion using live imaging and quantitative image analysis. E. histolytica, the etiological agent of amoebiasis, is a […]
Project
Completed
7 Members

Imaging and mathematical modelling of cell morphology and motility

(PI)

Elucidating the mechanisms underlying cell deformation and motility is a topic of major interest in cell biology, for they are strongly involved in cell development, immune responses, cancer and infectious diseases. This projects focuses on the […]

Publications

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