I am interested in cell mobility and morphology in an amoeba called Entamoeba histolytica, a highly mobile intestinal parasite responsible for dysenteric amoebiasis in humans.
My activity lies at the interface between biology for cell culture and experiments, microscopy and quantification of the signals observed using the Icy software, developed in our unit.
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2023Live Cells Imaging and Comparative Phosphoproteomics Uncover Proteins from the Mechanobiome in Entamoeba histolytica., Int J Mol Sci 2023 May; 24(10): .
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20224D live imaging and computational modeling of a functional gut-on-a-chip evaluate how peristalsis facilitates enteric pathogen invasion., Science advances.
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2022Domain Adapted Multi-task Learning For Segmenting Amoeboid Cells in Microscopy, IEEE Transactions on Medical Imaging, 2022.
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2022PI Kinase-EhGEF2-EhRho5 axis contributes to LPA stimulated macropinocytosis in Entamoeba histolytica, PLoS Pathog 18(5): e1010550.
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2020Zika Virus Inhibits IFN-α Response by Human Plasmacytoid Dendritic Cells and Induces NS1-Dependent Triggering of CD303 (BDCA-2) Signaling, Front Immunol. 2020 Oct 28;11:582061.
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2020A Protocol to Quantify Cellular Morphodynamics: From Cell Labelling to Automatic Image Analysis, Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology, 2020.
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2018Morphodynamics of the Actin-Rich Cytoskeleton in Entamoeba histolytica, Front Cell Infect Microbiol. 2018 May 29;8:179.
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2017BioFlow: a non-invasive, image-based method to measure speed, pressure and forces inside living cells., Sci Rep 2017 08; 7(1): 9178.
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2016Biophysical measurements in 2D and 3D live cell imaging using fluid dynamics and optical flow, 2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI), Prague, 2016, pp. 980-983.
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2016Intracellular traffic of the lysine and glutamic acid rich protein KERP1 reveals features of endomembrane organization in Entamoeba histolytica, Cell. Microbiol. 2016 Aug;18(8):1134-52.
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